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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44483
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dc.creatorEmisael Stênio Batista Gomespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorLuiz Henrique Silveirapt_BR
dc.creatorCarlos Ícaro de Jesuspt_BR
dc.creatorRogério Gonçalves da Rochapt_BR
dc.creatorGuilherme Veloso Ramospt_BR
dc.creatorHanna Thaynara Alves Teixeira Magalhãespt_BR
dc.creatorManoel Brito Júniorpt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorBruno Correia Jhampt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2022-08-23T13:20:13Z-
dc.date.available2022-08-23T13:20:13Z-
dc.date.issued2019-01-
dc.citation.volume97pt_BR
dc.citation.spage35pt_BR
dc.citation.epage41pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2018.10.004pt_BR
dc.identifier.issn0003-9969pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44483-
dc.description.resumoObjective: because the impact of conditioned fear stress on apical bone resorption is unknown, the aim of the current studywas to use a rat model to evaluate the impact of conditioned fear stress on the bone resorption of inflammatory apical periodontitis lesions. Methods: twenty-five animals were divided into two groups. They underwent a surgical procedure in the first left lower molar tooth to expose the dental pulp and induce inflammatory apical periodontitis lesions through the retention of contamination (bacterial infection) during a 56-day period. The animals in the case group were stressed daily by using electrical stimuli (1.10 mA), whereas the animals in the control group were absent from the stressful stimuli (shocks). The open field test was performed to validate the stress methodology. The jaws were removed and collected for histological and radiographic analyses. Results: stressed animals presented increased levels of bone loss and inflammatory cells in the root apex in comparison with the control group (P = 0.0001). However, no radiographic differences were observed between the groups (P > 0.05). Conclusions: our results demonstrated that conditioned fear stress could modify a periapical lesion by increasing the size of bone loss there. Conditioned fear stress also increased the total number of inflammatory cells compared with the control group. Studies evaluating the impact of conditioned fear stress on human periapical inflammatory lesions should be encouraged.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Oral Biologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherPeriodontitept_BR
dc.subject.otherEndodontiapt_BR
dc.subject.otherOsteoporosept_BR
dc.subject.otherStress (Psicologia)pt_BR
dc.titleConditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996918303662pt_BR
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