Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/44541| Type: | Artigo de Periódico |
| Title: | Molecular finds of pressure ulcer: a bioinformatics approach in pressure ulcer |
| Authors: | Eloa Mangabeira Santos Lucyana Conceição Farias Sérgio Henrique Sousa Santos Alfredo Maurício Batista de Paula Carla Silvana de Oliveira e Silva André Luiz Sena Guimarães |
| Abstract: | Background: understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. Objective: this study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. Methods: we performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin. Results: TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH, UBC, and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress. Conclusion: TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU. |
| Subject: | Úlceras Inflamação Bioinformática |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jtv.2017.01.002 |
| URI: | http://hdl.handle.net/1843/44541 |
| Issue Date: | May-2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0965206X17300165 |
| metadata.dc.relation.ispartof: | Journal of Tissue Viability |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Molecular finds of pressure ulcer.pdf | 1.9 MB | Adobe PDF | View/Open |
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