Nuclear sirtuins and inflammatory signaling pathways

Keila Lopes Mendes; Deborah de Farias Lelis; Sérgio Henrique Sousa Santos

Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44561

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DC Field	Value	Language
dc.creator	Keila Lopes Mendes	pt_BR
dc.creator	Deborah de Farias Lelis	pt_BR
dc.creator	Sérgio Henrique Sousa Santos	pt_BR
dc.date.accessioned	2022-08-25T13:40:55Z	-
dc.date.available	2022-08-25T13:40:55Z	-
dc.date.issued	2017-12	-
dc.citation.volume	38	pt_BR
dc.citation.spage	98	pt_BR
dc.citation.epage	105	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.cytogfr.2017.11.001	pt_BR
dc.identifier.issn	1879-0305	pt_BR
dc.identifier.uri	http://hdl.handle.net/1843/44561	-
dc.description.resumo	The regulation of chronic inflammation has received considerable research attention in recent years because of its contribution to the pathogenesis of chronic diseases such as arthritis, diabetes, metabolic syndrome and obesity. Thus, strategies that inhibit the inflammatory state may be beneficial in improving the pathophysiology of several inflammation-related disorders. Sirtuins are a family of histone deacetylases that contain seven enzymatic activities in mammals (SIRT1–SIRT7) and function to suppress gene transcription by epigenetic mechanisms. Nuclear sirtuins (SIRT 1, 2, 6 and 7) in particular may play an important role in the regulation of inflammatory responses. In the present review, we assessed the roles of nuclear sirtuins in inflammatory reactions: SIRT1 has been shown to suppress NF-κb activity, the master regulator of cellular inflammatory response, decrease COX-2 and iNOS production, and increase antioxidant gene expression that suppressed inflammation. SIRT2 activity included the deacetylation of p65 subunit of NF-κβ and RIP-1, while SIRT6 has been shown to interact with p65/RelA bound to the NF-κβ promoter region and repress transcriptional activity. Furthermore, recent studies have shown that the absence of SIRT7 produced an increase in inflammation, illustrating that SIRT7 also functioned to decrease inflammation. Given their significant roles in the regulation of chronic inflammation, nuclear sirtuins represent potential therapeutic targets in the control of chronic inflammatory diseases.	pt_BR
dc.description.sponsorship	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico	pt_BR
dc.description.sponsorship	FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais	pt_BR
dc.description.sponsorship	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	pt_BR
dc.language	eng	pt_BR
dc.publisher	Universidade Federal de Minas Gerais	pt_BR
dc.publisher.country	Brasil	pt_BR
dc.publisher.department	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS	pt_BR
dc.publisher.initials	UFMG	pt_BR
dc.relation.ispartof	Cytokine and Growth Factor Reviews	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.subject.other	Inflamação	pt_BR
dc.subject.other	Doenças crônicas	pt_BR
dc.subject.other	Síndrome metabólica	pt_BR
dc.subject.other	Obesidade	pt_BR
dc.subject.other	Diabetes	pt_BR
dc.subject.other	Artrite	pt_BR
dc.subject.other	Histonas	pt_BR
dc.title	Nuclear sirtuins and inflammatory signaling pathways	pt_BR
dc.type	Artigo de Periódico	pt_BR
dc.url.externa	https://www.sciencedirect.com/science/article/pii/S1359610117301740?via%3Dihub	pt_BR
Appears in Collections:	Artigo de Periódico

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