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Type:	Artigo de Periódico
Title:	Is HIF1-a deregulated in malignant salivary neoplasms?
Authors:	Cláudio Marcelo Cardoso Sabrina Ferreira de Jesus Marcela Gonçalves de Souza Eloa Mangabeira Santos Cristiane Karine Cordeiro Santos Christine Mendes Silveira Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula Lucyana Conceição Farias André Luiz Sena Guimarães
Abstract:	Background: there is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs). Objective: the current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms. Patients and methods: the current study sample is comprised of a total of 62 samples. HIF-1α expression was evaluated by immunohistochemistry. Additionally, HIF-1α mRNA and miR-210 levels were assessed using qRT-PCR. Results: no differences in HIF-1α expression were observed among the control group, benign and malignant SGNs. Similarly, HIF-1α mRNA levels were similar between benign and malignant SGNs. Also, there was no difference in miR-210 expression between case and control groups. Conclusion: the angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands.
Subject:	Tumores odontogênicos Câncer - Quimioterapia
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.gene.2019.03.017
URI:	http://hdl.handle.net/1843/44646
Issue Date:	15-May-2019
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S0378111919302434?via%3Dihub
metadata.dc.relation.ispartof:	Gene
Appears in Collections:	Artigo de Periódico

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