1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44653
Full metadata record
DC FieldValueLanguage
dc.creatorCristina da Costa Oliveirapt_BR
dc.creatorMarina Gomes Miranda e Castorpt_BR
dc.creatorCamila Gomes Miranda e Castorpt_BR
dc.creatorÁghata de França Costapt_BR
dc.creatorRenata Cristina Mendes Ferreirapt_BR
dc.creatorJosiane Fernandes da Silvapt_BR
dc.creatorJuliana Maria Navia Pelaezpt_BR
dc.creatorLuciano dos Santos Aggum Capettinipt_BR
dc.creatorVirginia Soares Lemospt_BR
dc.creatorIgor Dimitri Gama Duartept_BR
dc.creatorAndrea de Castro Perezpt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorThiago Roberto Lima Romeropt_BR
dc.date.accessioned2022-08-29T14:28:45Z-
dc.date.available2022-08-29T14:28:45Z-
dc.date.issued2019-04-15-
dc.citation.volume369pt_BR
dc.citation.spage30pt_BR
dc.citation.epage38pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.taap.2019.02.004pt_BR
dc.identifier.issn0041-008Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44653-
dc.description.resumoDespite all the development of modern medicine, around 100 compounds derived from natural products were undergoing clinical trials only at the end of 2013. Among these natural substances in clinical trials, we found the resveratrol (RES), a pharmacological multi-target drug. RES analgesic properties have been demonstrated, although the bases of these mechanisms have not been fully elucidated. The aim of this study was to evaluate the involvement of opioid and cannabinoid systems in RES-induced peripheral antinociception. Paw withdrawal method was used and hyperalgesia was induced by carrageenan (200 μg/paw). All drugs were given by intraplantar injection in male Swiss mice (n = 5). RES (100 μg/paw) administered in the right hind paw induced local antinociception that was antagonized by naloxone, non-selective opioid receptor antagonist, and clocinnamox, μOR selective antagonist. Naltrindole and nor-binaltorfimine, selective antagonists for δOR and kOR, respectively, did not reverse RES-induced peripheral antinociception. CB1R antagonist AM251, but not CB2R antagonist AM630, antagonized RES-induced peripheral antinociception. Peripheral antinociception of RES intermediate-dose (50 μg/paw) was increased by: (i) bestatin, inhibitor of endogenous opioid degradation involved-enzymes; (ii) MAFP, inhibitor of anandamide amidase; (iii) JZL184, inhibitor of 2-arachidonoylglycerol degradation involved-enzyme; (iv) VDM11, endocannabinoid reuptake inhibitor. Acute and peripheral administration of RES failed to affect the amount of μOR, CB1R and CB2R. Experimental data suggest that RES induces peripheral antinociception through μOR and CB1R activation by endogenous opioid and endocannabinoid releasing.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofToxicology and Applied Pharmacologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherOpióidespt_BR
dc.subject.otherCanabinóidespt_BR
dc.subject.otherFitonutrientespt_BR
dc.subject.otherHiperalgesiapt_BR
dc.titleEvidence for the involvement of opioid and cannabinoid systems in the peripheral antinociception mediated by resveratrolpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0041008X19300535pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.