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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44657
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dc.creatorMarina Campos Zickerpt_BR
dc.creatorAna Letícia Malheiros Silveirapt_BR
dc.creatorDébora Romualdo Lacerdapt_BR
dc.creatorDébora Fernandes Rodriguespt_BR
dc.creatorCíntia Tarabal Oliveirapt_BR
dc.creatorLetícia Maria de Souza Cordeiropt_BR
dc.creatorLeandro Ceotto Freitas Limapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorAdaliene Versiani Matos Ferreirapt_BR
dc.date.accessioned2022-08-29T14:49:46Z-
dc.date.available2022-08-29T14:49:46Z-
dc.date.issued2019-01-
dc.citation.volume63pt_BR
dc.citation.spage117pt_BR
dc.citation.epage128pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2018.08.013pt_BR
dc.identifier.issn1873-4847pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44657-
dc.description.resumoThe global rise in obesity rates is alarming since this condition is associated with chronic low-grade inflammation and secondary comorbidities as glucose intolerance, cardiovascular disease and liver damage. Therefore, a lot of dietary approaches are proposed to prevent and to treat obesity and its associated disorders. Virgin coconut oil (VCO) is well known as a functional food due to its significant amounts of medium-chain triglycerides. This study aimed to evaluate the effect of VCO on adiposity, metabolic and inflammatory dysfunctions induced by a high-refined carbohydrate-containing (HC) diet in mice. Male BALB/c mice were divided into two groups and fed with control (C) or HC diet to induce obesity for eight weeks. At the 9th week mice fed with HC diet were randomly regrouped into four groups, and were kept this way until the 12th week, as following: (i) HC diet alone or HC diet supplemented with three different VCO doses (ii) 1000 mg/kg, (iii) 3000 mg/kg and (iv) 9000 mg/kg. Regardless of the concentration used, VCO supplementation promoted lower adiposity and also improvement in glucose tolerance, lower serum glucose and lipid levels and decreased hepatic steatosis. Moreover, VCO intake induced a lower inflammatory response due to decreased number of leukocytes and TNF-α and IL-6 concentrations in adipose tissue, as well as reduced counts of total leukocytes, mononuclear and polymorphonuclear circulating cells. Our data showed that VCO can be considered as an interesting potential dietary approach to attenuate obesity and its metabolic and inflammatory alterations.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Journal of Nutritional Biochemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherTriglicerídeospt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherÓleo de cocopt_BR
dc.subject.otherAlimentos funcionaispt_BR
dc.titleVirgin coconut oil is effective to treat metabolic and inflammatory dysfunction induced by high refined carbohydrate-containing diet in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286318300986pt_BR
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