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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44664
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dc.creatorGabriela Cavazza Cerript_BR
dc.creatorLeandro Ceotto Freitas Limapt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorLucíola da Silva Barcelospt_BR
dc.creatorJohn David Feltenbergerpt_BR
dc.creatorSamuel Vidal Mussipt_BR
dc.creatorRenato Sobral Monteiro Júniorpt_BR
dc.creatorRobson Augusto Souza dos Santospt_BR
dc.creatorLucas Antônio Miranda Ferreirapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-29T15:12:45Z-
dc.date.available2022-08-29T15:12:45Z-
dc.date.issued2019-02-
dc.citation.volume218pt_BR
dc.citation.spage292pt_BR
dc.citation.epage299pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2018.12.063pt_BR
dc.identifier.issn0024-3205pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44664-
dc.description.resumoSclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects. Aims: the present study aimed to evaluate the effects of Sclareol in different formulations (solid lipid nanoparticle and free) on the metabolic profile of obese mice. Main methods: swiss male mice were randomly divided into two groups: standard diet (STD) and high-fat diet (HFD). After obesity induction, each group was divided into three treatment groups: free Sclareol (Sc), Sclareol-loaded lipid nanoparticle (L-Sc) and blank lipid nanoparticle (L). Treatments were performed every day during 30 days. Key findings: L-Sc improves obese mice metabolic profile by decreasing adiposity, ameliorating insulin sensitivity, glucose tolerance and increasing the HDL plasma levels. In addition, L-Sc decreased the expression of NF-KB, MCP-1 and SERBP-1. Significance: the use of sclareol together with lipid nanocarriers may be promising for the treatment of metabolic disorders by reducing adipose tissue.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofLife Sciencespt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherDiterpenospt_BR
dc.subject.otherEssências e óleos essenciaispt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherNanopartículaspt_BR
dc.titleSclareol-loaded lipid nanoparticles improved metabolic profile in obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0024320518308609pt_BR
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