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http://hdl.handle.net/1843/44672
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DC Field | Value | Language |
---|---|---|
dc.creator | Carolina Bosso André | pt_BR |
dc.creator | Pedro Luiz Rosalen | pt_BR |
dc.creator | Lívia Câmara de Carvalho Galvão | pt_BR |
dc.creator | Bruna Marin Fronza | pt_BR |
dc.creator | Glaucia Maria Bovi Ambrosano | pt_BR |
dc.creator | Jack Liborio Ferracane | pt_BR |
dc.creator | Marcelo Giannini | pt_BR |
dc.date.accessioned | 2022-08-29T17:37:10Z | - |
dc.date.available | 2022-08-29T17:37:10Z | - |
dc.date.issued | 2017-10 | - |
dc.citation.volume | 33 | pt_BR |
dc.citation.issue | 10 | pt_BR |
dc.citation.spage | 1084 | pt_BR |
dc.citation.epage | 1092 | pt_BR |
dc.identifier.doi | 10.1016/j.dental.2017.07.006 | pt_BR |
dc.identifier.issn | 01095641 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/44672 | - |
dc.description.resumo | Objectives: The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin. Methods: Apigenin (1mM) and tt-Farnesol (5mM) were added separately and in combination to a self-etch adhesive (CS3 - Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT - OptiBond S). Biofilm of S. mutans was grown on adhesive-coated hydroxyapatite disks for 115h and bacterial viability, dry-weight, alkali soluble, water soluble, intracellular polysaccharides and protein were quantified. Bond strength and dentin-adhesive interface were performed to analyze the effects of the incorporation on the physical properties and to identify changes in hybrid layer morphology. Results: Addition of Apigenin and Apigenin+tt-Farnesol to CS3, and Apigenin or tt-Farnesol to OPT reduced the dry-weight of S. mutans biofilm. Insoluble polysaccharide decreased with the addition of Apigenin to CS3 and tt-Farnesol to OPT. Intracellular polysaccharide decreased with addition of Apigenin and Apigenin+tt-Farnesol to CS3. No changes in dentin bond strength, resin-dentin interfacial morphology, total amount of protein and soluble polysaccharide were observed with the additions. Significance: Biofilms that are less cariogenic around dental restorations could decrease secondary caries formation; in addition, the reduction of virulence of S. mutans without necessarily killing the microorganism is more unlikely to induce antimicrobial resistance. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo | pt_BR |
dc.format.mimetype | pt_BR | |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Dental Materials | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | Apigenin | pt_BR |
dc.subject | Bacterial virulence | pt_BR |
dc.subject | Caries | pt_BR |
dc.subject | Tt-farnesol | pt_BR |
dc.subject | Dental adhesives | pt_BR |
dc.subject.other | Apigenin | pt_BR |
dc.subject.other | Dental cements | pt_BR |
dc.subject.other | Dental caries | pt_BR |
dc.subject.other | Streptococcus mutans | pt_BR |
dc.title | Modulation of streptococcus mutans virulence by dental adhesives containing anti-caries agents | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S0109564117300556?via%3Dihub | pt_BR |
Appears in Collections: | Artigo de Periódico |
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