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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44672
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dc.creatorCarolina Bosso Andrépt_BR
dc.creatorPedro Luiz Rosalenpt_BR
dc.creatorLívia Câmara de Carvalho Galvãopt_BR
dc.creatorBruna Marin Fronzapt_BR
dc.creatorGlaucia Maria Bovi Ambrosanopt_BR
dc.creatorJack Liborio Ferracanept_BR
dc.creatorMarcelo Gianninipt_BR
dc.date.accessioned2022-08-29T17:37:10Z-
dc.date.available2022-08-29T17:37:10Z-
dc.date.issued2017-10-
dc.citation.volume33pt_BR
dc.citation.issue10pt_BR
dc.citation.spage1084pt_BR
dc.citation.epage1092pt_BR
dc.identifier.doi10.1016/j.dental.2017.07.006pt_BR
dc.identifier.issn01095641pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44672-
dc.description.resumoObjectives: The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin. Methods: Apigenin (1mM) and tt-Farnesol (5mM) were added separately and in combination to a self-etch adhesive (CS3 - Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT - OptiBond S). Biofilm of S. mutans was grown on adhesive-coated hydroxyapatite disks for 115h and bacterial viability, dry-weight, alkali soluble, water soluble, intracellular polysaccharides and protein were quantified. Bond strength and dentin-adhesive interface were performed to analyze the effects of the incorporation on the physical properties and to identify changes in hybrid layer morphology. Results: Addition of Apigenin and Apigenin+tt-Farnesol to CS3, and Apigenin or tt-Farnesol to OPT reduced the dry-weight of S. mutans biofilm. Insoluble polysaccharide decreased with the addition of Apigenin to CS3 and tt-Farnesol to OPT. Intracellular polysaccharide decreased with addition of Apigenin and Apigenin+tt-Farnesol to CS3. No changes in dentin bond strength, resin-dentin interfacial morphology, total amount of protein and soluble polysaccharide were observed with the additions. Significance: Biofilms that are less cariogenic around dental restorations could decrease secondary caries formation; in addition, the reduction of virulence of S. mutans without necessarily killing the microorganism is more unlikely to induce antimicrobial resistance.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofDental Materialspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectApigeninpt_BR
dc.subjectBacterial virulencept_BR
dc.subjectCariespt_BR
dc.subjectTt-farnesolpt_BR
dc.subjectDental adhesivespt_BR
dc.subject.otherApigeninpt_BR
dc.subject.otherDental cementspt_BR
dc.subject.otherDental cariespt_BR
dc.subject.otherStreptococcus mutanspt_BR
dc.titleModulation of streptococcus mutans virulence by dental adhesives containing anti-caries agentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0109564117300556?via%3Dihubpt_BR
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