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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44678
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dc.creatorAndressa Dos Santospt_BR
dc.creatorEmerson Marcelo Girottopt_BR
dc.creatorCarolina Bosso Andrépt_BR
dc.creatorGedalias Martimpt_BR
dc.creatorIvania Teresinha Albrecht Schuquelpt_BR
dc.creatorCarmen Pfeiferpt_BR
dc.creatorJackl Ferracanept_BR
dc.creatorTania Tominagapt_BR
dc.creatorNajeh Maissar Khalilpt_BR
dc.creatorEduardo Radovanovicpt_BR
dc.date.accessioned2022-08-29T18:46:46Z-
dc.date.available2022-08-29T18:46:46Z-
dc.date.issued2018-09-26-
dc.citation.volume87pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doi10.1016/j.ijadhadh.2018.09.009pt_BR
dc.identifier.issn01437496pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44678-
dc.description.resumoThe aim of this in vitro study was to synthesize three new methacrylate monomers based on the modification of saccharides structures (glucose-Gluc, sucrose-Sucr and chitosan-Chit) with glycidyl methacrylate, and to use them in the composition of dental adhesives. Three methacrylate saccharide monomers were synthesized and characterized by mid-IR, 1H and 13C NMR, antioxidant activity and cytotoxic effect. Monomers included: one monosaccharide – Gluc-MA; one disaccharide – Sucr-MA; and one polysaccharide – Chit-MA. Primers containing HEMA, methacrylate saccharide monomers at concentrations of 0 (control), 1, 2 or 4 wt%, 60 wt% ethanol aqueous solution (pH3.0) and initiator system were formulated. Primers were used in conjunction with a bond step and composite paste to restore caries-free third molars, and dentin bond strength (24 hours and 6 month of storage in water), and antimicrobial activity (Alamar Blue test) were tested. Degree of conversion (DC) and maximum rate of polymerization (Rpmax) of the primers themselves were also analyzed. The mid-IR, 1H and 13C spectrum confirmed the presence of vinyl group on the structure of saccharides. Chit-MA showed low antioxidant activity and did not present a cytotoxic effect. Gluc-MA and Sucr-MA possess antioxidant and cytotoxic activity, concentration dependent. In the presence of methacrylate saccharide monomers, the primers showed DC comparable to the control group, except Gluc-MA4%, Sucr-MA4% and Chit-MA1%, which showed a range of 64.6 from 58.5 %DC. Rpmax was not statistically different for all the groups (p = 0.01). The bond strength of Sucr-MA1% increased from 25.7 (±2.8) to 40.6 (±5.3) MPa after 6 months of storage. All the synthesized monomers showed some antimicrobial activity after polymerization. Gluc-MA and Chit-MA 4% and Sucr-MA 1, 2 and 4% led to decrease bacterial metabolism. Sucr-MA 1% showed better results regarding the decrease in bacterial metabolism and increasing the bond strength after 6 months of storage.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Adhesion and Adhesivespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntibacterial adhesivespt_BR
dc.subjectDentinept_BR
dc.subjectNuclear magnetic resonance spectroscopypt_BR
dc.subjectMechanical properties of adhesivespt_BR
dc.subject.otherMethacrylatespt_BR
dc.subject.otherCarbohydratespt_BR
dc.subject.otherDental restoration repairpt_BR
dc.titleMethacrylate saccharide-based monomers for dental adhesive systemspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533006/pt_BR
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