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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44695
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dc.creatorDeborah de Farias Lelispt_BR
dc.creatorDaniela Fernanda de Freitaspt_BR
dc.creatorAmanda Souto Machadopt_BR
dc.creatorThaísa Soares Crespopt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-30T13:30:15Z-
dc.date.available2022-08-30T13:30:15Z-
dc.date.issued2019-06-
dc.citation.volume19pt_BR
dc.citation.spage36pt_BR
dc.citation.epage45pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.metabol.2019.03.006pt_BR
dc.identifier.issn0026-0495pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44695-
dc.description.resumoNowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses angiotensin-(1–7), which is now recognized as the main peptide on counteracting Ang II effects. New studies have shown that increased activation of ACE2/Ang-(1–7)/MasR arm can revert and prevent local and systemic dysfunctions improving lipid profile and insulin resistance by modulating insulin actions, and reducing inflammation. In this context, the present review shows the interaction and relevance of Ang-(1–7) effects on regulating adipokines, and as one adipokine itself, modulating body homeostasis, with emphasis on its anti-inflammatory properties, especially in the context of metabolic disorders with focus on obesity and type 2 diabetes mellitus pandemic.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMetabolismpt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherEnzima conversora da angiotensinapt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherHomeostasept_BR
dc.subject.otherObesidadept_BR
dc.subject.otherDiabetespt_BR
dc.titleAngiotensin-(1-7), adipokines and inflammationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0026049519300629?via%3Dihubpt_BR
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