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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44725
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dc.creatorGabriela Cavazza Cerript_BR
dc.creatorDaisy Motta Santospt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorLuiz Fernando de Rezendept_BR
dc.creatorRobson Augusto Souza dos Santospt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-30T15:08:44Z-
dc.date.available2022-08-30T15:08:44Z-
dc.date.issued2020-10-
dc.citation.volume84pt_BR
dc.citation.spage108413pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2020.108413pt_BR
dc.identifier.issn1873-4847pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44725-
dc.description.resumoObesity is a chronic multifactorial disease and is currently a public health problem. Maternal obesity during pregnancy is more dangerous as it impairs the health of the mother and future generations. Obesity leads to several metabolic disorders. Since white adipose tissue is an endocrine tissue, obesity often leads to disordered secretion of inflammatory, glycemic, lipid and renin–angiotensin system (RAS) components. The RAS represents a link between obesity and its metabolic consequences. Therefore, our goal was to evaluate the possible changes caused by a high-fat diet in RAS-related receptor expression in the uterus and placenta of pregnant mice and determine the underlying effects of these changes in the fetuses’ body composition. Breeding groups were formed after obesity induction by high-fat (HF) diet. Dams and fetuses were euthanized on the 19th day of the gestational period. The HF diet effectively induced obesity, glucose intolerance and insulin resistance in mice. Fetuses born from HF dams showed increased body weight and adiposity. Both results were accompanied by increased AT1R expression in placenta and uterus together with increased angiotensin-converting enzyme expression in the uterus and a decreased expression of MAS1 in placenta of HF dams. These results suggest a link between RAS, maternal obesity induced by HF diet and the fetuses’ body adiposity. This new path now can be more thoroughly explored.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Journal of Nutritional Biochemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherAngiotensinapt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherGravidezpt_BR
dc.subject.otherTecido adiposopt_BR
dc.titleMaternal obesity modulates both the renin–angiotensin system in mice dams and fetal adipositypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286320304459pt_BR
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