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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44767
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dc.creatorJaciara Neves Sousapt_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorDeborah Farias Lelispt_BR
dc.creatorEloa Mangabeira Santospt_BR
dc.creatorJuliana Pinto Limapt_BR
dc.creatorRenato Sobral Monteiro Júniorpt_BR
dc.creatorMarcos Flávio Silveira Vasconcelos D'Angelopt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-31T14:43:18Z-
dc.date.available2022-08-31T14:43:18Z-
dc.date.issued2020-06-
dc.citation.volume134pt_BR
dc.citation.spage110881pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exger.2020.110881pt_BR
dc.identifier.issn0531-5565pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44767-
dc.description.resumoIntroduction: gallic acid (GA) is a natural endogenous polyphenol found in a variety of fruits, vegetables and wines, with beneficial effects on the energetic homeostasis. Aim: the present study aimed to investigate oral gallic acid effects on liver steatosis and hepatic lipogenesis markers in obese mice evaluating new possible molecular related mechanisms. Methods: twenty-four Swiss male mice were divided into four groups and fed for 60 days with standard diet (ST), standard diet plus gallic acid (ST + GA), high-fat diet (HFD), and high-fat diet plus gallic acid (HFD + GA). We evaluated the relationship between body weight, food intake and serum levels of total cholesterol, triglycerides, insulin, aspartate and alanine transaminases. Liver histology was analyzed by hematoxylin and eosin staining. These results were accompanied by bioinformatics analyses. The acetyl-CoA carboxylase (ACC), sterol regulatory element binding protein-1 (SREBP-1) and fatty acid synthase (FAS) expression was assessed by quantitative real-time reverse transcriptase PCR (qRT-PCR). Results: the main findings of the present study showed that GA reduced liver steatosis, body weight and plasma insulin levels. Analyzes of hepatic steatosis related genes expression showed that ACC and FAS mRNA were significantly suppressed in liver of HFD + GA mice. These data was corroborated by bioinformatics analysis. Conclusion: these data suggest an important clinical application of GA in the prevention and treatment of liver diseases.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofExperimental Gerontologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherEsteatose hepáticapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherBioinformáticapt_BR
dc.subject.otherÁcido gálicopt_BR
dc.titleOral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0531556519307971?via%3Dihubpt_BR
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