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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44898
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dc.creatorDaniel Silva Moraespt_BR
dc.creatorDaniele Cristina Moreirapt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-09-05T12:41:04Z-
dc.date.available2022-09-05T12:41:04Z-
dc.date.issued2020-12-
dc.citation.volume9pt_BR
dc.citation.spage46pt_BR
dc.citation.epage51pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ibror.2020.06.004pt_BR
dc.identifier.issn2451-8301pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44898-
dc.description.resumoSirtuins (SIRTs) are a protein family with high preservation degree among evolutionary scale. SIRTs are histone deacetylases regulatory enzymes of genetic material deeply involved in numerous physiological tasks including metabolism, brain function and aging. Mammals sirtuins comprise seven enzymatic components (SIRT1–SIRT7). The highest studied sirtuin is SIRT1, which plays an essential position in the prevention and evolution of neuro-disorders. Resveratrol (3,5,4-trihydroxystylbene) (RSV) is a polyphenol, which belongs to a family compounds identified as stilbenes, predominantly concentrated in grapes and red wine. RSV is the must studied Sirtuin activator and is used as food supplementary compound. Resveratrol exhibits strong antioxidant activity, reducing free radicals, diminishing quinone-reductase-2 activity and exerting positive regulation of several endogenous enzymes. Resveratrol is also able to inhibit pro-inflammatory factors, reducing the stimulation of the nuclear factor kB (NF-kB) and the release of endogenous cytokines. Resveratrol treatment can modulate multiple signaling pathway effectors related to programmed cell death, cell survival, and synaptic plasticity. In this context, the present review looks over news and the role of Sirtuins activation and resveratrol effects on modulating target genes, cognition and neurodegenerative disorders.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofIBRO Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSistema nervoso centralpt_BR
dc.subject.otherCogniçãopt_BR
dc.subject.otherPolifenóispt_BR
dc.subject.otherFitonutrientespt_BR
dc.subject.otherSuplementos dietéticospt_BR
dc.subject.otherRadicais livres (Química) - Efeito fisiológicopt_BR
dc.titleSirtuins, brain and cognition: a review of resveratrol effectspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2451830120300194pt_BR
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