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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44950
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dc.creatorAmanda Souto Machadopt_BR
dc.creatorJanaína Ribeiro Oliveirapt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2022-09-06T14:24:22Z-
dc.date.available2022-09-06T14:24:22Z-
dc.date.issued2020-07-23-
dc.citation.volume23pt_BR
dc.citation.issue1pt_BR
dc.citation.spage100pt_BR
dc.citation.epage108pt_BR
dc.identifier.doihttps://doi.org/10.1177/1099800420942942pt_BR
dc.identifier.issn1552-4175pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44950-
dc.description.resumoBackground: obesity and non-alcoholic fatty liver disease (NAFLD) have been increasing at an alarming rate worldwide. Bifidobacterium longum (BL), a common member of the human gut microbiota, has important health benefits through several mechanisms. Objectives: we evaluated the BL supplementation effects on body metabolism and renin-angiotensin components hepatic expression in mice fed a high-fat diet. Methods: thirty-two male mice were divided into four groups: standard diet + placebo (ST), standard diet + Bifidobacterium longum (ST + BL), high-fat diet + placebo (HFD) and high-fat diet + Bifidobacterium longum (HFD + BL). Following the obesity induction period, the ST + BL and HFD + BL groups were supplemented with Bifidobacterium longum for 4 weeks. Then, body, biochemical, histological and molecular parameters were evaluated. Results: HFD + BL mice had a significant decrease in adipose tissue mass and blood glucose levels, as well as a significant reduction in blood glucose during an intraperitoneal glucose tolerance test. The treatment also resulted in reduced levels of total cholesterol and hepatic fat accumulation. Moreover, we observed an increase in angiotensin converting enzyme 2 (ACE2) and Mas receptor (MASR) expression levels in BL-treated obese mice. Conclusions: these data demonstrate that BL may have the potential to prevent obesity and NAFLD by modulating the mRNA expression of renin-angiotensin system components.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiological Research for Nursingpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherFígado - Doençaspt_BR
dc.subject.otherTecido adiposopt_BR
dc.titleOral probiotic Bifidobacterium longum supplementation improves metabolic parameters and alters the expression of the renin-angiotensin system in obese mice liverpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.sagepub.com/doi/full/10.1177/1099800420942942pt_BR
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