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Type:	Artigo de Periódico
Title:	Enalapril improves obesity associated liver injury ameliorating systemic metabolic markers by modulating Angiotensin Converting Enzymes ACE/ACE2 expression in high-fat feed mice
Authors:	Daniel Silva Moraes Deborah de Farias Lelis João Marcus Oliveira Andrade Lara Meyer André Luiz Senna Guimarães Alfredo Maurício Batista de Paula Lucyana Conceição Farias Sérgio Henrique Sousa Santos
Abstract:	Obesity is a chronic disease caused multiple associated factors that results in excessive body fat accumulation. The Renin-Angiotensin System (RAS) unbalance is now recognized as a key factor on regulating body energy and metabolism. Aim: the aim of the present study was to evaluate the Enalapril (ACE inhibitor) effects on the metabolic function and hepatic steatosis of obese mice evaluating Angiotensin Converting Enzymes (ACEs) expression. Methods: the experiment was performed using 32 male Swiss mice (8 weeks old) equally and randomly divided into 4 groups (n = 8): standard diet (ST), standard diet plus Enalapril (ST + ENAL), hyperlipidic diet (HF) and hyperlipidic diet plus Enalapril (HF + ENAL). Weekly measurements of animal weight and feed consumption were performed. At the end of treatment period a glucose tolerance test (GTT) and insulin sensitivity test (IST) were performed. Ultrasonography was used to evaluate hepatic and epididymal fat pad. Liver samples were submitted to HE histology and gene expression analyses were performed using Real-Time PCR. Results: the main results showed a decrease in body weight after treatment with Enalapril, as well as a reduced size of epididymal fat pad (EFP). Hepatic echogenicity and steatosis measurement were lower in the obese groups treated with Enalapril also modulating ACE2/ACE expressions. Conclusions: Enalapril use improved metabolism reducing hepatic steatosis, decreasing ACE expression and increasing ACE2 expression.
Subject:	Obesidade Sistema renina-angiotensina Esteatose hepática
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.prostaglandins.2020.106501
URI:	http://hdl.handle.net/1843/45007
Issue Date:	Feb-2021
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S1098882320300940?via%3Dihub
metadata.dc.relation.ispartof:	Prostaglandins and Other Lipid Mediators
Appears in Collections:	Artigo de Periódico

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