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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45416
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dc.creatorJuan Felipe Dumes Monteropt_BR
dc.creatorLuiz Cláudio de Almeida Barbosapt_BR
dc.creatorUlisses Alves Pereirapt_BR
dc.creatorGuilherme Mariz de Oliveira Barrapt_BR
dc.creatorMarcio Celso Fredelpt_BR
dc.creatorCesar Augusto Magalhães Benfattipt_BR
dc.creatorRicardo de Souza Maginipt_BR
dc.creatorAndréa de Lima Pimentapt_BR
dc.creatorJúlio César Matias de Souzapt_BR
dc.date.accessioned2022-09-23T13:53:50Z-
dc.date.available2022-09-23T13:53:50Z-
dc.date.issued2016-07-26-
dc.citation.volume104pt_BR
dc.citation.issue12pt_BR
dc.citation.spage3015pt_BR
dc.citation.epage3020pt_BR
dc.identifier.doihttps://doi.org/10.1002/jbm.a.35842pt_BR
dc.identifier.issn1552-4965pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45416-
dc.description.resumoPoly-ether-ether-ketone (PEEK) is currently introduced as an alternative material for orthopedic implants due to its biocompatibility and low elastic modulus compared to titanium. Also, a sulphonation treatment can functionalize PEEK to embed therapeutical substances. The objective of this work was to functionalize a PEEK film to incorporate novel lactam-based antibiofilms compounds. PEEK samples were functionalized by sulphuric acid treatment and then dissolved in dimethylsulfoxide, where lactams were added to be incorporated into the polymer. A dip-coating technique was used to synthesize a thin film on a glass-based substrate. The degree of sulfonation (DS) and the incorporation of lactams into sulphonated PEEK (sPEEK) were analyzed by Fourier transform infrared spectroscopy, nuclear magnetic resonance, thermogravimetric analysis (TGA), and scanning electron microscopy. A DS of 65% was obtained and TGA curves confirmed the presence of SO3H and lactams in the sPEEK structure. The growth of Streptococcus mutans biofilm decreased on sPEEK surface containing lactams when compared to sPEEK free of lactams. That indicated the antibiofilm activity of those compounds was maintained after incorporation into sPEEK. Planktonic growth analysis showed no long distant effects of sPEEK containing lactams, indicating that no systemic effects should be expected upon clinical uses of medical devices produced with lactam-treated sPEEK. Results revealed that inclusion of lactams into sPEEK represents a good alternative for the production of biomaterials resistant to bacterial accumulation.pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Biomedical Materials Research Part Apt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPEEKpt_BR
dc.subjectlactamspt_BR
dc.subjectStreptococcus mutanspt_BR
dc.subjectrubrolidespt_BR
dc.subjectBiofilm inhibitionpt_BR
dc.subject.otherStreptococcus mutanspt_BR
dc.subject.otherBiofilmept_BR
dc.subject.otherImplantes ortopédicospt_BR
dc.subject.otherEspectroscopia de infravermelhopt_BR
dc.subject.otherLactamaspt_BR
dc.subject.otherMateriais biomédicospt_BR
dc.titleChemical, microscopic, and microbiological analysis of a functionalizedpoly-ether-ether-ketone-embedding antibiofilm compoundspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.35842pt_BR
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