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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45441
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dc.creatorMarcela Carvalho Espaladoript_BR
dc.creatorKamilla Faria Macielpt_BR
dc.creatorLuciana Carla Neves de Britopt_BR
dc.creatorToshihisa Kawaipt_BR
dc.creatorLeda Quercia Vieirapt_BR
dc.creatorAntônio Paulino Ribeiro Sobrinhopt_BR
dc.date.accessioned2022-09-24T16:53:14Z-
dc.date.available2022-09-24T16:53:14Z-
dc.date.issued2018-
dc.citation.volume32pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.issn18073107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45441-
dc.description.resumoThe aim of this study is to evaluate the expression of cytokines in response to mineral trioxide aggregate (MTA) plus selenium in germ-free mice with experimental furcal perforation. The first left maxillary molar was opened, and the furcal area was perforated and treated with post-MTA-Se (experimental group). The same surgical intervention was performed for the maxillary right first molar, which was treated with MTA (control group). Fifteen mice were sacrificed 7, 14, and 21 days after furcal perforation, and periapical tissue samples were collected. The mRNA expression levels of the cytokines TGF-β, TNF-α, IFN-γ, HPRT, IL-10, IL-4, RANK, RANKL, IL-1, and IL-17 were assessed by using real-time polymerase chain reaction. In the experimental group, at 21-days post-MTA-Se sealing, the mRNA levels of TNF-α and IL-10 were upregulated compared with those in the control group (p < 0.05). Futher assessment revealed basal mRNA expression levels of IL-1α, IFN-γ, RANK, RANKL, IL-17A, IL-4, and TGF-β, over long experimental times, in both the experimental and control groups (p > 0.05). In conclusion, MTA+Se sealing favoured increased expression of IL-10 and TNF-α at later time points (day 21).pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSeleniumpt_BR
dc.subjectCytokinespt_BR
dc.subjectImmunophenotypingpt_BR
dc.subjectModelspt_BR
dc.subjectAnimalpt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherSeleniumpt_BR
dc.subject.otherImmunophenotypingpt_BR
dc.subject.otherAnimalspt_BR
dc.titleExperimental furcal perforation treated with mineral trioxide aggregate plus selenium: immune responsept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/zQS8nNbJFnMrjmhmQPWRFnn/abstract/?lang=enpt_BR
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