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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45481
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dc.creatorFrancine Benettipt_BR
dc.creatorJoão Eduardo Gomes Filhopt_BR
dc.creatorFerreirapt_BR
dc.creatorGustavo Sivieri de Araújopt_BR
dc.creatorEdilson Ervolinopt_BR
dc.creatorAndré Luiz Fraga Brisopt_BR
dc.creatorLuciano Tavares Angelo Cintrapt_BR
dc.date.accessioned2022-09-24T20:14:29Z-
dc.date.available2022-09-24T20:14:29Z-
dc.date.issued2018-01-20-
dc.citation.volume51pt_BR
dc.citation.issue07pt_BR
dc.citation.spage789pt_BR
dc.citation.epage799pt_BR
dc.identifier.doi10.1111/iej.12891pt_BR
dc.identifier.issn01432885pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45481-
dc.description.resumoAim: To evaluate lymphocyte-like cell activation (CD5-positive cells) and the expression of interleukin (IL)-6 and IL-17 in the pulp after tooth bleaching with two concentrations of hydrogen peroxide (H2 O2 ). Methodology: The right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20% H2 O2 (BLUE group, 1 application of 50 min), 35% H2 O2 (MAXX group, three applications of 15 min), or placebo gel (control). After 2 and 30 days, the rats were killed (n = 10), and the jaws were processed for histological and immunohistochemistry analysis of the pulp tissue. The scores of inflammation and immunolabelling (IL-6/IL-17) were submitted to Mann-Whitney and Kruskal-Wallis followed Dunn tests, respectively; anova tests were used for comparisons of number of CD5-positive cells and pulp chamber area values (P < 0.05). Results: At 2 days, 60% of specimens of the BLUE group were associated with moderate inflammation in pulp horns, and in the MAXX group with necrosis (P < 0.05). At 30 days, the pulp was organized, and tertiary dentine was formed. The MAXX group had superior immunolabelling of IL-17 at 2 days differing significantly from other groups (P < 0.05). At 2 days, 90% of the specimens of the BLUE group had moderate immunolabelling of IL-6, and 50% of the MAXX group had severe immunolabelling, both significantly different from the control (P < 0.05). There was no significant difference between the groups at 30 days (P > 0.05). CD5-positive cells were present at 2 and 30 days, particularly in the bleached groups (P < 0.05), without significant difference between time periods (P > 0.05). Conclusions: IL-6 and IL-17 participated in inflammation in the pulp tissue of rats after tooth bleaching, particularly at 2 days. The immunolabelling was greater with increasing H2 O2 concentration. This process was accompanied by the prolonged activation of CD5-positive cells.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCD5pt_BR
dc.subjectDental pulppt_BR
dc.subjectHydrogen peroxidept_BR
dc.subjectInterleukin-17pt_BR
dc.subjectInterleukin-6pt_BR
dc.subjectTooth bleachingpt_BR
dc.subject.otherTooth bleachingpt_BR
dc.subject.otherInterleukin-17pt_BR
dc.subject.otherInterleukin-6pt_BR
dc.subject.otherDental pulp cavitypt_BR
dc.subject.otherHydrogen peroxidept_BR
dc.titleConcentration-dependent effect of bleaching agents on the immunolabeling of interleukin-6, interleukin-17, and cd5-positive cells in the dental pulppt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12891pt_BR
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