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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45641
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dc.creatorMarjorie de Oliveira Gallinaript_BR
dc.creatorLuciano Tavares Ângelo Cintrapt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorVanessa Rahalpt_BR
dc.creatorEdilson Ervolinopt_BR
dc.creatorAndré Luiz Fraga Brisopt_BR
dc.date.accessioned2022-09-27T21:53:03Z-
dc.date.available2022-09-27T21:53:03Z-
dc.date.issued2019-01-08-
dc.citation.volume14pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0210338pt_BR
dc.identifier.issn19326203pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45641-
dc.description.resumoThis study aimed to evaluate neuropeptide expression after bleaching treatment using histo pathological and immunohistochemical analyses and the effects of hydrocortisone and acet aminophen on pulp inflammation, sine dental bleaching and inflammation first occur, and only then, the treatmentt. Sixty-three rats were divided into three groups (n = 21) according to the pain-relieving therapy used: I-control; II-topical application of Otosporin for 10 min after the bleaching treatment; III-oral administration of paracetamol 30 min before whitening and then every 12h. In all the study groups, placebo gel was applied to the left upper jaw (control) and a 35% H2O2-based whitening gel was applied to the right upper jaw for 45 min. Seven animals from each group were euthanized at different time points: 0h after treatment, 24h, and 48h. After euthanasia, the first molar on each side was analyzed by histology and immunohistochemistry to assess the degree of inflammation and verify the presence of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP). The data were analyzed using the statistical nonparametric Kruskal-Wallis test followed by Dunn’s test for individual comparisons. Extensive areas of necrosis were observed in the groups that received bleaching treatment only, whereas reduced damage were obtained in the group treated with Otosporin. The immunohistochemical analysis showed positive immuno labeling in all groups, including the control, but this was stronger in the groups that received bleaching treatment. The best results were obtained in the group that received treatment with Otosporin. The use of Otosporin after dental bleaching minimized the side effects of this treatment.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherTooth bleachingpt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherHidrocortisonapt_BR
dc.subject.otherAcetaminofénpt_BR
dc.subject.otherInflammationpt_BR
dc.titlePulp response of rats submitted to bleaching and the use of different anti-inflammatory drugspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210338pt_BR
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