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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45818
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dc.creatorLeopoldo Cosme Silvapt_BR
dc.creatorJoão Eduardo Gomes-Filhopt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorDal-Fabbropt_BR
dc.creatorVivien Thiemy Sakaipt_BR
dc.creatorLuciano Tavarez Angelo Cintrapt_BR
dc.creatorEdilson Ervolinopt_BR
dc.creatorNaiana Viana Violapt_BR
dc.date.accessioned2022-09-30T18:43:50Z-
dc.date.available2022-09-30T18:43:50Z-
dc.date.issued2018-12-04-
dc.citation.volume52pt_BR
dc.citation.issue05pt_BR
dc.citation.spage689pt_BR
dc.citation.epage700pt_BR
dc.identifier.doihttps://doi.org/10.1111/iej.13052pt_BR
dc.identifier.issn01432885pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45818-
dc.description.resumoAimTo evaluate the inflammatory response andability to induce mineral deposition through histologi-cal and immunohistochemical analysis for osteocalcin(OCN), osteopontin (OPN) and bone sialoprotein (BSP)of a new calcium silicate-based cement, Bio-C Pulpo(Angelus), compared to white mineral trioxide aggre-gate (White MTA-Ang) (Angelus).MethodologyPolyethylene tubes containing Bio-CPulpo and White MTA-Ang as well as empty tubeswere implanted into the dorsal connective tissue of30 Wistar rats, which were arranged in five groupsaccording to the period of analysis: 7, 15, 30, 60and 90 days. After each experimental period, thetubes with surrounding tissue were removed and his-tologically processed to be analysed usinghaematoxylin–eosin and immunohistochemistry forthe detection of OCN, OPN and BSP. The data werestatistically analysed (Friedman’s test) at a 5% signifi-cance level.ResultsThe inflammatory response observed withBio-C Pulpo and White MTA-Ang was greater after 7and 15 days and decreased from 30 days onwards.No significant difference was found between the con-trol, Bio-C Pulpo and White MTA-Ang at the differentperiods of analysis (P>0.05). The immunolabellingfor OCN, OPN and BSP was more intense for Bio-CPulpo and White MTA-Ang after 60 and 90 days,but there was no difference between Bio-C Pulpo andWhite MTA-Ang at the different periods of analysis(P>0.05).ConclusionBio-C Pulpo is biocompatible andinduces immunolabelling of osteogenic markers suchas OCN, OPN and BSP similar to White MTA-Ang.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBiocompatibilitypt_BR
dc.subjectBone sialoproteinpt_BR
dc.subjectOsteocalcinpt_BR
dc.subjectOsteopontinpt_BR
dc.subjectpulpotomypt_BR
dc.subject.otherOsteocalcinpt_BR
dc.subject.otherOsteopontinpt_BR
dc.subject.otherMaterials testingpt_BR
dc.subject.otherPulpotomypt_BR
dc.titleBiocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, bio-c pulpopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.13052pt_BR
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