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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45824
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dc.creatorFrancine Benettipt_BR
dc.creatorÍndia Olinta de Azevedo Queirozpt_BR
dc.creatorPedro Henrique Chaves de Oliveirapt_BR
dc.creatorLeticia Citelli Contipt_BR
dc.creatorMariane Maffei Azumapt_BR
dc.creatorSandra Helena Penha de Oliveirapt_BR
dc.creatorLuciano Tavares Ângelo Cintrapt_BR
dc.date.accessioned2022-09-30T19:20:31Z-
dc.date.available2022-09-30T19:20:31Z-
dc.date.issued2019-05-16-
dc.citation.volume33pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2019.vol33.0042pt_BR
dc.identifier.issn18073107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45824-
dc.description.resumoThis study evaluated the cytotoxicity and biocompatibility of a new bioceramic endodontic sealer (i.e., Sealer Plus BC) in comparison with those of MTA Fillapex and AH Plus. L929 fibroblasts were cultured and Alamar Blue was used to evaluate cell viability of diluted extracts (1:50, 1:100, and 1:200) from each sealer at 24 h. Polyethylene tubes that were filled with material or empty (as a control) were implanted in the subcutaneous tissue of rats. The rats were killed after 7 and 30 d (n = 8), and the tubes were removed for histological analysis. Parametric data was analyzed using a one-way ANOVA test, and nonparametric data was analyzed via the Kruskal–Wallis test followed by the Dunn test (p < 0.05). A reduction in cell viability was observed in the extracts that were more diluted for Sealer Plus BC when compared to that of Control and AH Plus (p < 0.05). However, the 1:50 dilution of the Sealer Plus BC was similar to that of the Control (p > 0.05). Conversely, more diluted extracts of MTA Fillapex (1:200) and AH Plus (1:100 and 1:200) were similar to the Control (p > 0.05). Histological analysis performed at 7 d did not indicate any significant difference between tissue response for all materials, and the fibrous capsule was thick (p > 0.05). At 30 d, Sealer Plus BC was similar to the Control (p > 0.05) and MTA Fillapex and AH Plus exhibited greater inflammation than the Control (p < 0.05). The fibrous capsule was thin for the Control and for most specimens of Sealer Plus BC and AH Plus. Thus, Sealer Plus BC is biocompatible when compared to MTA Fillapex and AH Plus, and it is less cytotoxic when less-diluted extracts are used.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCell culture techniquespt_BR
dc.subjectEndodonticspt_BR
dc.subjectInflammationpt_BR
dc.subjectMaterials testingpt_BR
dc.subject.otherEndodonticspt_BR
dc.subject.otherMaterials testingpt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherCell culture techniquespt_BR
dc.titleCytotoxicity and biocompatibility of a new bioceramic endodontic sealer containing calcium hydroxidept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/DhsNtpyxZQPtsndgXwpybDB/?lang=enpt_BR
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