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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45900
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dc.creatorLidiane Mendes Louzadapt_BR
dc.creatorAndré Luiz Fraga Brisopt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorLetícia Vieirapt_BR
dc.creatorRogério de Castilho Jacintopt_BR
dc.creatorElói Dezan-Júniorpt_BR
dc.creatorLuciano Tavares Ângelo Cintrapt_BR
dc.date.accessioned2022-10-03T19:04:31Z-
dc.date.available2022-10-03T19:04:31Z-
dc.date.issued2019-01-28-
dc.citation.volume10pt_BR
dc.citation.issue2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1111/jicd.12401pt_BR
dc.identifier.issn20411618pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45900-
dc.description.resumoAim: Carvedilol is an antioxidant that decreases inflammation in periodontitis. The hydrogen peroxide (H2 O2 ) of bleaching gel causes inflammation and necrosis of the dental pulp. In the present study, we evaluated the anti-inflammatory potential of carvedilol in the pulp of rats after bleaching. Methods: The right upper molars of rats received 35% H2 O2 (1× 30 minutes), and the left upper molars were used as the control. Half of the rats received carvedilol gel (1× 10 minutes), forming the following groups: bleached, bleached followed by carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi-maxillae/group), the rats were killed for histological evaluation, and statistical tests were performed (P < 0.05). Results: After 2 days, the bleached group showed necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol group, severe inflammation (P > 0.05), both different from the control (P < 0.05). In the middle third, the bleached group showed severe inflammation, and the bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only difference between the bleached and control groups (P < 0.05). In the cervical third, the bleached group showed moderate inflammation, and the bleached+carvedilol group showed mild inflammation (P > 0.05). The difference again was only between the bleached and control groups (P < 0.05). At 30 days, there was no inflammation and a marked amount of tertiary dentin in bleached teeth (P > 0.05). Conclusion: Carvedilol gel has the potential of minimizing H2 O2 damage, especially in deep regions of the dental pulp of rats after bleaching.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Investigative and Clinical Dentistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCarvedilolpt_BR
dc.subjectHydrogen peroxidept_BR
dc.subjectInflammationpt_BR
dc.subjectPulppt_BR
dc.subjectTooth bleachingpt_BR
dc.subject.otherCarvedilolpt_BR
dc.subject.otherHydrogen peroxidept_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherDental pulp cavitypt_BR
dc.subject.otherTooth bleachingpt_BR
dc.titleAnti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: a histopathological evaluationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jicd.12401pt_BR
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