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http://hdl.handle.net/1843/45944| Type: | Artigo de Periódico |
| Title: | Immunohistochemical study of fibronectin, tenascin and type i collagen in tongue and lip carcinomas |
| Authors: | João Luiz de Miranda Felipe Rodrigues de Matos Frederico Santos Lages Dhelfeson Willya Douglas de Oliveira Roseana de Almeida Freitas |
| Abstract: | AIM: The aim was to compare the immunoexpression of extracellular matrix proteins in squamous cell carcinomas of tongue (SCCTo) and lower lip (SCCLi). METHODS: Eleven SCCTo and 11 SCCLi were selected and examined according to Bryne’s method (1998). For immunohistochemical study utilized antibodies to fibronectin, tenascin and type I collagen. Histopathologic and immunohistochemical analysis were performed on the tumor invasive front. RESULTS: All SCCTo were classified in high score malignant grade and all SCCLi in lower score. Fibronectin showed strong immunorreactivity in the peritumoral basement membrane (BM) in 91% of SCCTo and all cases of SCCLi, while in the tumor stroma (TS) all cases of SCCTo and SCCLi had strong intensity. Tenascin had strong expression in BM of 91% cases of SCCTo and 63.4% of SCCLi and in TS had strong expression in 91% cases of SCCTo and 54.6% of SCCLi. Type I collagen demonstrated weak immunoreactivity in the TS of 72.7% cases of SCCTo and 63.4% of SCCLi. CONCLUSION: These results may suggest that the strong expression of fibronectin and tenascin proteins and the weak expression of type I collagen could play a role in the invasive process of oral SCC. |
| Subject: | Immunohistochemistry Mouth neoplasms Fibronectins Collagen |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - FACULDADE DE ODONTOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.20396/bjos.v16i0.8651061 |
| URI: | http://hdl.handle.net/1843/45944 |
| Issue Date: | 15-Dec-2017 |
| metadata.dc.url.externa: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8651061 |
| metadata.dc.relation.ispartof: | Brazilian Journal of Oral Sciences |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Immunohistochemical study of fibronectin, tenascin and type i collagen in tongue and lip carcinomas.pdf | 1.26 MB | Adobe PDF | View/Open |
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