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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46343
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dc.creatorCelline Cardoso Almeida Brasilpt_BR
dc.creatorJuliana Oliveira Costapt_BR
dc.creatorElizabeth Nascimentopt_BR
dc.creatorRomara Elizeu Amaro Perdigãopt_BR
dc.creatorMicheline Rosa Silveirapt_BR
dc.creatorPalmira de Fátima Bonolopt_BR
dc.creatorFrancisco de Assis Acurciopt_BR
dc.creatorMaria Das Graças Braga Ceccatopt_BR
dc.date.accessioned2022-10-18T22:14:18Z-
dc.date.available2022-10-18T22:14:18Z-
dc.date.issued2017-08-22-
dc.citation.issue33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Managementpt_BR
dc.citation.spage343pt_BR
dc.citation.epage343pt_BR
dc.identifier.doihttps://doi.org/10.1002/pds.4275pt_BR
dc.identifier.issn1099-1557pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46343-
dc.description.resumoBackground: The once-daily single-tablet regimen (STR) containing efavirenz, tenofovir and lamivudine is the first choice for HIV-infected people initiating antiretroviral therapy (ART) in Brazil and few studies have examined its influence on treatment and healthrelated characteristics compared to multiple-tablet regimen (MTR). Objectives: To evaluate the differences of antiretroviral therapy as a STR and MTR regarding treatment and health-related characteristics. Methods: Baseline evaluation of a cohort of 184 HIVinfected adults (79% male, mean age 35.9) with six or less months of ART under care in a reference hospital in Belo Horizonte, Brazil. Recruitment occurred between Sep/2015 and Aug/2016, and data were obtained through face-to-face interviews. Quality of life (QoL), symptoms of anxiety and depression, health state and adherence were assessed through self-report using validated instruments. A 40-item instrument to be validated during the cohort was used to assess perceived barriers with ART. The regimen used was collected from the Brazilian ART delivery database system (SICLOM). STR and MTR users were compared through non-parametric tests using Stata v.14. Results: A slightly lower proportion of STR versus MTR patients were non-adherent (54% vs 57%) and had adverse effects (85% vs. 88%), anxiety symptoms (36% vs. 41%) and depression symptoms (27% vs. 31%), though the statistical difference was not significant (p > 0.05). The STR group showed a higher QoL in the independence domain (p<0.01) (WHOQoLHIV-bref) and a better self-perception of health (p<0.05) (EQ5D VAS) than MTR group. The MTR group had twice the odds of having difficulties with the treatment (p<0.05). The perceived barriers associated with MTR were “incorporate ART into work routine” (p<0.05), “swallow the pills” (p= 0.05) and “social isolation (p<0.01)”. Conclusions: All the characteristics analyzed in this study tended to be better for patients using STR. Although adherence was not significantly higher in STR group, patients reporting difficulties with treatment had twice the odds of being non-adherent. The results indicate that single-tablet regimens may help patients in the management of ART, reflecting in aspects of daily life activities and self-perception of health.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Conference on Pharmacoepidemiology & Therapeutic Risk Managementpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHIVpt_BR
dc.subjectTerapia antirretroviralpt_BR
dc.subjectMedicamentospt_BR
dc.subject.otherHIVpt_BR
dc.subject.otherTerapia antirretroviralpt_BR
dc.subject.otherMedicamentospt_BR
dc.titleA comparison of single versus multipletablet regimens in HIV-infected people initiating antiretroviral therapypt_BR
dc.typeArtigo de Eventopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275pt_BR
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