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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46422
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dc.creatorMichael Ruberson Ribeiro da Silvapt_BR
dc.creatorLuísa Monteirode Barros Tavares de Melopt_BR
dc.creatorJéssica Barreto Ribeiro dos Santospt_BR
dc.creatorLeonardo Maurício Dinizpt_BR
dc.creatorJuliana Alvarespt_BR
dc.creatorFrancisco de Assis Acurciopt_BR
dc.date.accessioned2022-10-19T20:56:49Z-
dc.date.available2022-10-19T20:56:49Z-
dc.date.issued2017-08-22-
dc.citation.issue33pt_BR
dc.citation.spage127pt_BR
dc.citation.epage127pt_BR
dc.identifier.doihttps://doi.org/10.1002/pds.4275pt_BR
dc.identifier.issn1099-1557pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46422-
dc.description.resumoBackground: NPH insulin is an important therapeutic alternative for the maintenance of glycemic control in patients with type 2 diabetes mellitus (DM2) in the Brazilian Public Health System (SUS). It is currently considered the third-line treatment in SUS or considered for patients with plasma glucose above 300 mg/ dL at the time of diagnosis. Objectives: To assess the prevalence of NPH insulin use and associated factors among patients with DM2. Methods: Cross-sectional study was conducted in 63 municipalities of Minas Gerais in 2014. The dependent variable was defined as the use of NPH insulin. The independent variables were gender, age, marital status, education, race, self-reported health, diagnosis time, hypoglycemic crisis in the last month, comorbidities, medical visits in the past year, type of health care (public or private), regular physical activity, polypharmacy (use five or more drugs) and interruption of routine activities in the last 15 days. Bivariate and multivariate logistic regression analysis was performed to identify factors associated with NPH insulin use. Results: A total of 2192 patients with DM2 were interviewed and 25% used either insulin or analogue to insulin. The prevalence of NPH insulin use among the participants was 22.1%. Approximately 62% of the NPH insulin users took the medication twice a day, and 33% took it once a day. The following factors were associated with the use of NPH insulin among those patients: diagnostic time above 10 years (OR = 2.78; CI 95% 2.22–3.47), having hypoglycemic crisis in the last month (OR = 2.39; CI 95% 1.85–3.09), using less than 5 drugs (OR = 1.71; CI 95% 1.34– 2.19), having more than 5 comorbidities (OR = 1.48; CI 95% 1.15–1.90), consulting with the doctor more than 3 times on the previous year (OR = 1.46; CI 95% 1.15–1.85) and diabetic foot (OR = 1.53; CI 95% 1.08–2.16) and diabetic neuropathy (OR = 1.40; CI 95% 1.06–1.85) as complications of the DM2. Conclusions: NPH was the most used insulin among the participants. NPH insulin use are associated disease progression characteristics such as having longer diagnostic time, difficulty in glycemic control and complications. Trained professionals are needed to provide adequate care for diabetic patients, especially when using NPH insulin, and therefore to promote a rational use of medicines and to minimize the negative consequences of treatment discontinuation on the health of this population.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Conference on Pharmacoepidemiology & Therapeutic Risk Managementpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectInsulinapt_BR
dc.subjectInsulina NPHpt_BR
dc.subject.otherDiabetes mellituspt_BR
dc.subject.otherInsulinapt_BR
dc.titleNPH insulin use by patients with type 2 diabetes mellitus in Minas Gerais, Brazil: prevalence and associated factorspt_BR
dc.typeArtigo de Eventopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275pt_BR
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