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http://hdl.handle.net/1843/46442| Type: | Artigo de Periódico |
| Title: | Microparticles are related to cognitive and functional status from normal aging to dementia |
| Authors: | Carolina Antunes Magalhães Fernanda Freire Campos Nunes Cristina de Mello Gomide Loures Vanessa Gomes Fraga Leonardo Cruz de Souza Henrique Cerqueira Guimarães Marco Túlio Gualberto Cintra Maria Aparecida Camargos Bicalho Maria das Graças Carvalho Lirlândia Pires de Sousa Paulo Caramelli Karina Braga Gomes Borges |
| Abstract: | Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment. PMPs, LMPs and TFMPs, were associated with cognitive impairment in this population. LMPs and NMP, were associated to lower functional performance in the elderly sample. These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders. |
| Abstract: | Recentemente, mostramos que os níveis de micropartículas (MPs) derivadas de leucócitos (LMPs), endotélio (EMPs), neurônios (NMPs) e aquelas que expressam fator tecidual (TFMPs) foram maiores em pacientes com Doença de Alzheimer (DA) quando comparados a indivíduos cognitivamente saudáveis. Portanto, neste estudo propusemos investigar a correlação entre níveis de MPs, desempenho cognitivo e estado funcional em uma amostra de idosos. Foram avaliados MPs derivados de plaquetas (PMPs), LMPs, EMPs, NMPs e TFMPs em 43 participantes, dos quais 12 com provável demência por DA, 16 com comprometimento cognitivo leve (CCL) e 15 sem comprometimento cognitivo ou funcional objetivo. PMPs, LMPs e TFMPs foram associados ao comprometimento cognitivo nesta população. LMPs e NMP, foram associados ao menor desempenho funcional na amostra de idosos. Esses resultados sugerem que os MPs podem estar envolvidos na fisiopatologia de distúrbios neurodegenerativos. |
| Subject: | Demência Cognição Estado funcional |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jneuroim.2019.577027 |
| URI: | http://hdl.handle.net/1843/46442 |
| Issue Date: | 15-Nov-2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0165572819300426 |
| metadata.dc.relation.ispartof: | Journal of Neuroimmunology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Microparticles are related to cognitive and functional status from normal aging to dementia.pdf | 377.06 kB | Adobe PDF | View/Open |
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