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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46505
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dc.creatorLucas Moreira Maiapt_BR
dc.creatorMarcela Carvalho Espaladoript_BR
dc.creatorJulia Maria Braga Dinizpt_BR
dc.creatorWarley Luciano Fonseca Tavarespt_BR
dc.creatorLuciana Carla Neves de Britopt_BR
dc.creatorLeda Quércia Vieirapt_BR
dc.creatorAntônio Paulino Ribeiro Sobrinhopt_BR
dc.date.accessioned2022-10-21T20:18:53Z-
dc.date.available2022-10-21T20:18:53Z-
dc.date.issued2020-02-22-
dc.citation.volume22pt_BR
dc.citation.spage3691pt_BR
dc.citation.epage3697pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00784-020-03247-ypt_BR
dc.identifier.issn14326981pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46505-
dc.description.resumoObjectives: To identify the gene expression of the cytokines IL-9, TNF-α, IL-1, INF-γ, IL-17A, and IL-10 and the chemokines CCL-2/MCP-1 and CCR-6 in the periapical fluid of human root canal infections. Materials and methods: Twenty samples were collected immediately and 7 days after the cleaning and shaping procedures (after reducing the intracanal microbial load) in an attempt to characterize the expression of these genes. The endogenous expression levels of cytokines and chemokines were analyzed by real-time polymerase chain reaction. The Shapiro-Wilk and the Wilcoxon tests analyzed data. Results: Significantly higher levels of the IL-9, INF-γ, TNF-α, IL-1, and IL-10 markers on day 7 were observed compared with day 0 (p < 0.05). However, IL-17A and the chemokines CCL-2/MCP-1 and CCR-6 did not show a significant difference in mRNA expression when comparing both timepoints (p > 0.05). Conclusions: The clinical variation of the periapical immune status after endodontic therapy suggests that the cytokine and chemokine-mediated pro-inflammatory response appears to be modulated in an IL-10/IL-9-dependent manner. Clinical relevance: Few studies have investigated the role of Th9 cells in periapical lesions. IL-9 presents exciting plasticity, performing immunosuppressive actions, and it is also capable of changing their phenotype in the presence of IL-17. Hence, it is relevant to investigate its role in the context of the known mediators involved the periapical immune processpt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Oral Investigationspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectApical periodontitispt_BR
dc.subjectCytokine and chemokinept_BR
dc.subjectIL-9pt_BR
dc.subjectInterleukinpt_BR
dc.subjectTH9pt_BR
dc.subject.otherPeriapical periodontitispt_BR
dc.subject.otherChemokinespt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherInterleukinspt_BR
dc.titleClinical endodontic procedures modulate periapical cytokine and chemokine gene expressionspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00784-020-03247-ypt_BR
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