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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46525
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dc.creatorLaís Lessa Pantuzzapt_BR
dc.creatorMaria das Graças Braga Ceccatopt_BR
dc.creatorMicheline Rosa Silveirapt_BR
dc.creatorLuane Mendes Ribeiro Junqueirapt_BR
dc.creatorCelline Cardoso Almeida Brasilpt_BR
dc.creatorAdriano Max Moreira Reispt_BR
dc.date.accessioned2022-10-24T13:43:25Z-
dc.date.available2022-10-24T13:43:25Z-
dc.date.issued2017-08-22-
dc.citation.issue33pt_BR
dc.citation.spage522pt_BR
dc.citation.epage523pt_BR
dc.identifier.doihttps://doi.org/10.1002/pds.4275pt_BR
dc.identifier.issn1099-1557pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46525-
dc.description.resumoBackground: Having a high medication regimen complexity has been negatively associated to health outcomes, such as hospitalizations and poor quality of life. However, its influence on adherence has not been well established. Objectives: To systematically review and summarize the evidence regarding the association between medication regimen complexity and adherence in any pharmacotherapy. Methods: Articles were searched using MEDLINE, LILACS, Cochrane, CINAHL, PsycINFO and included studies references. Search terms included medication regimen complexity and medication adherence. Randomized clinical trials, cross-sectional, cohort or case-control studies published before March 2016 in English, Portuguese or Spanish languages were eligible if quantitatively examined the correlation between medication regimen complexity and medication adherence in patients of any age and sex, under any type of medication therapy. All type of instruments used to assess complexity and adherence were considered. Quality assessment was conducted independently using standard scales according of the study design. Results: Fifty-four studies met the inclusion criteria: 37 cross-sectional and 17 cohort studies. Most of them (51) were conducted in outpatient setting. Most frequently, the studies were carried out with HIV-infected individuals (10) or patients with chronic conditions: diabetes mellitus (7), epilepsy (3) and hypertension (2). Forty-two studies used only one method to assess complexity, the most frequent ones were a complexity index (18 studies), such as Medication Regimen Complexity Index and Antiretroviral Regimen Complexity Index, and the number of medications (13 studies). Among the instruments used to measure adherence, the most frequent was self-report (29). Regimen complexity was associated with medication adherence in 36 studies. Most of them (29 studies) identified that participants with more complex regimens were less likely to adhere to medication therapy; seven studies found a direct correlation, so that more complex regimens where related with higher adherence. The other studies found inconclusive results or no correlation between complexity and adherence. Conclusions: Although there was variability in studies’ conclusions regarding the correlation between medication regimen complexity and medication adherence, most of them showed a low to moderate-quality evidence that, regardless the type of pharmacotherapy, an increased regimen complexity reduces the probability of medication adherence.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIALpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Conference on Pharmacoepidemiology & Therapeutic Risk Managementpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMedicamentospt_BR
dc.subjectRevisão Sistemáticapt_BR
dc.subjectComplexidade do regime terapêuticopt_BR
dc.subjectAdesão à medicaçãopt_BR
dc.subject.otherMedicamentospt_BR
dc.subject.otherAdesão à medicaçãopt_BR
dc.subject.otherComplexidade do regime terapêuticopt_BR
dc.titleInfluence of medication regimen complexity on adherence: a systematic reviewpt_BR
dc.typeArtigo de Eventopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275pt_BR
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