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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46876
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dc.creatorAlexandre Bizzotto de Carvalhopt_BR
dc.creatorÍvina Paula de Souzapt_BR
dc.creatorLídia Maria de Andradept_BR
dc.creatorIldefonso Binattipt_BR
dc.creatorEmerson Fernandes Pedrosopt_BR
dc.creatorKlaus Wilhelm Heinrich Krambrockpt_BR
dc.creatorWillian Xerxes Coelho Oliveirapt_BR
dc.creatorElene Cristina Pereira Maiapt_BR
dc.creatorPriscila Pereira Silva Caldeirapt_BR
dc.date.accessioned2022-11-03T19:02:51Z-
dc.date.available2022-11-03T19:02:51Z-
dc.date.issued2018-
dc.citation.volume156pt_BR
dc.citation.spage312pt_BR
dc.citation.epage319pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.poly.2018.09.046pt_BR
dc.identifier.issn02775387pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/46876-
dc.description.resumoHerein we describe the synthesis, structural characterization, physical/spectroscopic studies and evaluation of the antitumoral activity of a new copper(II) coordination polymer, [Cu(ndx)(8-hq)]n, where H(ndx) is nalidixic acid and H(8-hq) is 8-hydroxyquinoline. Single crystal X-ray diffraction shows a zigzag polymeric chain, where the adjacent copper atoms are connected via anti-anti μ-carboxylate bridge of ndx. This structural feature is quite different from those previously proposed for quinolone complexes. Variable-temperature magnetic susceptibility measurements showed weak antiferromagnetic interactions between the paramagnetic copper centers (−0.49 cm−1). In solution, the compound exists as neutral mononuclear species and it can inhibit the growth of a human chronic myelogenous leukemia cell line (K562) in a concentration-dependent manner with IC50 value lower than those of the corresponding free ligands. At similar doses, the compound does not alter the viability of human keratinocytes (HaCaT cell line). Spectroscopic data and viscosity measurements show that the compound binds to DNA (Kb = 2.47 × 105 M−1) interacting with it by a non-intercalative mode.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPolyhedronpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectNalidixic acidpt_BR
dc.subject8-hydroxyquinolinept_BR
dc.subjectCopper(II) coordination polymerpt_BR
dc.subjectAntitumoral activitypt_BR
dc.subjectMagnetic propertiespt_BR
dc.subject.otherPropriedades magnéticaspt_BR
dc.titleNovel copper(II) coordination polymer containing the drugs nalidixic acid and 8-hydroxyquinoline: evaluation of the structural, magnetic, electronic, and antitumor propertiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0277538718305989pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8699-6165pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0454-0026pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8379-6638pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7562-0285pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0722-5352pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2699-6232pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9983-3840pt_BR
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