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http://hdl.handle.net/1843/47108| Type: | Artigo de Periódico |
| Title: | Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans |
| Authors: | Shirley Alejandra Torres Morales Viviane de Souza Alves Sidney Augusto Vieira Filho Rafael Cesar Gonçalves Pereira Lucienir Pains Duarte Grasiely Faria de Sousa Djalma Menezes de Oliveira Fernanda Cristina Gontijo Evangelista Adriano de Paula Sabino Roberta Oliveira Viana Mariana Guerra de Aguilar |
| Abstract: | Maytenus distichophylla is a medicinal species used in Northeast of Brazil. The hexane (HE), chloroform (CE), ethyl acetate (EAE) and methanol (ME) extracts and compounds from its roots were evaluated for their protective activity against Staphylococcus aureus and Candida albicans. The cytotoxicity for chronic myeloid leukemia (K562), acute monocytic leukemia (THP-1), and peripheral blood mononuclear cells of normal individuals (PBMC) cells was established by MTT method using etoposide as standard. The in vivo toxicity of samples was determined using Caenorhabditis elegans model. From HE and CE were isolated: friedelan-3-one (1), b-sitosterol (2), 3-oxo-olean-9(11),12-diene (3), a mixture of pristimerin (4) and 11a-hydroxylup-20(29)-en-3-one (5), 30-hydroxylup-20(29)-en-3-one (6), friedelane-3,7-dione (7), tingenone (8) and triacylglycerol (9). The structures of 1-9 were confirmed by spectral data. All samples reduced the viability of S. aureus and present no effect against C. albicans. The HE, CE, mixture of 4/5 and 8 reduced 75% of S. aureus viability. Cytotoxic effect for K562 and THP-1 cells was caused by compounds 1, 2 and 8. All samples displayed selectivity for leukemic cells and low toxicity to PBMC cells, suggesting their potential as anticancer agents. Extracts and compounds were non-toxic to L1 larvae of C. elegans. However, most of them reduced significantly young adult worm’s survival, being considered as potential nematicides. |
| Subject: | Celastraceae Terpenios Maytenus Leucemia Citotoxidade de mediação celular |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE MICROBIOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.21577/0100-4042.20170591 |
| URI: | http://hdl.handle.net/1843/47108 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.scielo.br/j/qn/a/wsCkNh5MJdfJC5wXSngZqbJ/# |
| metadata.dc.relation.ispartof: | Química Nova |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CONSTITUENTS FROM ROOTS OF Maytenus distichophylla, ANTIMICROBIAL ACTIVITY AND TOXICITY FOR.pdf | 793.01 kB | Adobe PDF | View/Open |
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