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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47208
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dc.creatorLivia Maria Alves Valentim da Silvapt_BR
dc.creatorLuciano Tavares Angelo Cintrapt_BR
dc.creatorMarjorie Oliveira Gallinaript_BR
dc.creatorFrancine Benettipt_BR
dc.creatorVanessa Rahalpt_BR
dc.creatorEdilson Ervolinopt_BR
dc.creatorSibele Alcantarapt_BR
dc.creatorAndré Luiz Fraga Brisopt_BR
dc.date.accessioned2022-11-11T22:57:18Z-
dc.date.available2022-11-11T22:57:18Z-
dc.date.issued2020-02-28-
dc.citation.volume45pt_BR
dc.citation.issue2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.5395/rde.2020.45.e20pt_BR
dc.identifier.issn22347658pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47208-
dc.description.resumoObjectives To minimize the tooth sensitivity caused by in-office bleaching, many dentists use non-steroidal anti-inflammatory drugs and topical desensitizing gels containing potassium nitrate and sodium fluoride. This study aimed to evaluate the influence of these substances on inflammation and the expression of substance P and calcitonin gene-related peptide in pulp nerve fibers. Materials and Methods Seventy-two rats were divided into 6 groups as follows: GI, control; GII, only dental bleaching; GIII, only ibuprofen; GIV, ibuprofen administered 30 minutes before and after the bleaching treatment and every 12 hours until the analysis; GV, only topical application of a desensitizing agent; and GVI, topical application of a desensitizing agent before dental bleaching. Placebo gel was applied to the upper left jaw and the bleaching agent was applied to the upper right jaw in all groups. Subsequently, the groups were divided into 3 subgroups based on the time of analysis: 0, 24, and 48 hours after bleaching (n = 8). The rats were euthanized and the maxillae were processed and evaluated by histopathological and immunohistochemical analyses. The data were analyzed using the Kruskal-Wallis test, followed by the Dunn test (p < 0.05). Results In the bleaching groups, the inflammatory process and expression of neuropeptides decreased over time. The animals in which a desensitizing agent was applied showed better results within 24 hours. Conclusions The use of a desensitizing agent had positive effects on inflammation and pain-related neuropeptide expression, minimizing the painful effects of dental bleaching treatmentpt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRestorative Dentistry & Endodonticspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHydrogen peroxidept_BR
dc.subjectTooth bleachingpt_BR
dc.subjectIbuprofenpt_BR
dc.subjectLaboratory researchpt_BR
dc.subjectPainpt_BR
dc.subjectReactive oxygen speciespt_BR
dc.subject.otherTooth bleachingpt_BR
dc.subject.otherHydrogen peroxidept_BR
dc.subject.otherIbuprofenpt_BR
dc.subject.otherResearchpt_BR
dc.subject.otherPainpt_BR
dc.subject.otherReactive oxygen speciespt_BR
dc.titleInfluence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatmentpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239683/pt_BR
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