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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47512
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dc.creatorLeticia Citelli Contipt_BR
dc.creatorJuan José Segura Egea.pt_BR
dc.creatorCarolina de Barros Morais Cardosopt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorMariane Maffei Azumapt_BR
dc.creatorPedro Henrique Chaves de Oliveirapt_BR
dc.creatorSuely Regina Mogami Bomfimpt_BR
dc.creatorLuciano Tavares Ângelo Cintrapt_BR
dc.date.accessioned2022-11-28T19:56:53Z-
dc.date.available2022-11-28T19:56:53Z-
dc.date.issued2020-06-23-
dc.citation.volume53pt_BR
dc.citation.issue10pt_BR
dc.citation.spage1387pt_BR
dc.citation.epage1397pt_BR
dc.identifier.doihttps://doi.org/10.1111/iej.13350pt_BR
dc.identifier.issn01432885pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47512-
dc.description.resumoAim: To investigate the relationship between apical periodontitis and atherosclerosis in rats by lipid profile and carotid artery intima tunic measurement, and histological and histometric evaluation of periapical lesions. Methodology: Forty male Wistar rats were allocated into four groups: control (C), with apical periodontitis (AP), with atherosclerosis (AT) and with AP and AT (AP + AT). Atherosclerosis was induced using a high-lipid diet associated with a surgical ligature in the carotid artery and a super dosage of vitamin D3 . AP was induced via pulp exposure to the oral environment. At 45 and 75 days, serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. The maxillary and mandibular jaws and carotid artery were collected and processed for histological analysis. The Kruskal-Wallis or Mann-Whitney test was performed for nonparametric data, and the Tukey's or Student's t-test was performed for parametric data (P < 0.05). Results: In nonatherosclerotic animals, the induction of apical periodontitis increased TG levels significantly, from 63.1 ± 11.4 mg dL-1 in group C to 88.2 ± 7.9 mg dL-1 in the AP group (P < 0.05). The induction of AP was associated with a trend for higher TC and LDL-C levels in atherosclerotic animals (P > 0.05); however, it only significantly increased TG levels, from 93.2 ± 18.0 mg dL-1 in AT group to 121.9 ± 14.5 mg dL-1 in the AP + AT group (P < 0.05). Animals in the AP + AT group had a 36.5% increase in the thickness of the carotid intima tunic when compared with the AT group (P < 0.05). The intensity of the inflammatory infiltrate was significantly larger in the AP + AT group when compared with AP group (P < 0.05). The AP + AT group exhibited significantly greater alveolar bone loss, with a periapical lesion size of 206.4 ± 56.3 × 104 μm2 , compared with 151.4 ± 49.1 × 104 μm2 in the AP group (P < 0.05). Conclusion: Apical periodontitis influenced triglyceride levels, increasing them even in the absence of atherosclerosis, and influenced the increase in the thickness of the carotid artery intima tunic in the presence of atherosclerosis. Atherosclerosis intensified the inflammatory reaction and increased bone resorption in periapical lesionspt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectApical periodontitispt_BR
dc.subjectAtherosclerosispt_BR
dc.subjectEndodontic medicinept_BR
dc.subjectSystemic disorderspt_BR
dc.subject.otherPeriapical periodontitispt_BR
dc.subject.otherAtherosclerosispt_BR
dc.subject.otherEndodonticspt_BR
dc.subject.otherLipidspt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherEndodonticspt_BR
dc.titleRelationship between apical periodontitis and atherosclerosis: lipid profile and histological studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.13350pt_BR
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