1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47854
Full metadata record
DC FieldValueLanguage
dc.creatorVirgínia Mara Pereirapt_BR
dc.creatorFernando Marcos dos Reispt_BR
dc.creatorGeovanni Dantas Cassalipt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorMaíra Casalechi Badin Tellespt_BR
dc.creatorRobson Augusto Souza dos Santospt_BR
dc.creatorAdelina Martha dos Reispt_BR
dc.date.accessioned2022-12-09T13:34:38Z-
dc.date.available2022-12-09T13:34:38Z-
dc.date.issued2020-09-01-
dc.citation.volume51pt_BR
dc.citation.spage639pt_BR
dc.citation.epage647pt_BR
dc.identifier.doi10.1007/s10735-020-09910-8pt_BR
dc.identifier.issn1567-2387pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47854-
dc.description.resumoWe have previously demonstrated the presence of Angiotensin (Ang)-(1-7) in rat ovary homogenates and its stimulatory effect on estradiol and progesterone production. The present study was undertaken to identify the cellular localization of Ang-(1-7) and its receptor Mas in the rat ovary in the different phases of the estrous cycle. Ang-(1-7) and Mas were localized by immunohistochemistry and Mas mRNA expression was assessed by RT-PCR. Immunostaining for both Ang-(1-7) and Mas was found in all phases of the estrous cycle, particularly in the thecal and interstitial cells, as well as in regressing corpora lutea. However, granulosa cells were positive only in antral and preovulatory follicles at proestrus and estrus phases. This pattern contrasted with the distribution of the octapeptide Ang II, which was abundant in granulosa but not in theca cells. In addition, the expression of Mas mRNA was demonstrated in all estrous cycle phases. Angiotensin-converting enzyme activity did not vary between estrous cycle phases, whereas prolyl endopeptidase activity was significantly higher in diestrus and neutral endopeptidase activity was significantly higher in metestrus. These data provide the first evidence that new RAS components are dynamically expressed in the ovary across the rat estrous cycle. Further functional studies should clarify the role of Ang-(1-7) signaling through Mas receptor in the regulation of ovarian physiology.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Molecular Histologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAngiotensin-(1-7)pt_BR
dc.subjectAngiotensin IIpt_BR
dc.subjectACE 2pt_BR
dc.subjectovarypt_BR
dc.subjectMas receptorpt_BR
dc.subject.otherAngiotensinapt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherOváriospt_BR
dc.titleLocalization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cyclept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s10735-020-09910-8pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.