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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47881
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dc.creatorLuciano Fonseca Lemos de Oliveirapt_BR
dc.creatorJames Thackeraypt_BR
dc.creatorJosé Antônio Marin Netopt_BR
dc.creatorMinna Moreira Dias Romanopt_BR
dc.creatorEduardo Elias Vieira de Carvalhopt_BR
dc.creatorJorge Mejiapt_BR
dc.creatorDenise Mayumi Tanakapt_BR
dc.creatorGrace Kelly da Silvapt_BR
dc.creatorDouglas Reis Abdallapt_BR
dc.creatorCarlos Malamutpt_BR
dc.creatorFrank Bengelpt_BR
dc.creatorMaria de Lourdes Higuchipt_BR
dc.creatorAndré Schmidtpt_BR
dc.creatorEdécio Cunha Netopt_BR
dc.creatorMarcus Vinicius Simõespt_BR
dc.date.accessioned2022-12-12T18:55:57Z-
dc.date.available2022-12-12T18:55:57Z-
dc.date.issued2018-09-
dc.citation.volume59pt_BR
dc.citation.issue9pt_BR
dc.citation.spage1430pt_BR
dc.citation.epage1436pt_BR
dc.identifier.doihttps://doi.org/10.2967/jnumed.117.205450pt_BR
dc.identifier.issn0161-5505pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47881-
dc.description.resumoAltered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPDs) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters (n = 34) were infected with 3.5 × 104 to 105 trypomastigote forms of Trypanosoma cruzi, Y strain, and 6–10 mo afterward underwent in vivo imaging including resting 99mTc-sestamibi SPECT, segmental and global left ventricular function assessment using 2-dimensional echocardiography, and 18F-FDG PET for evaluation of myocardial viability. Histologic analysis included quantification of fibrosis, inflammatory infiltration, and the diameter and density of myocardial microcirculation. Results: MPDs were present in 17 (50%) of the infected animals. Histologic analysis revealed no transmural scar in segments with an MPD, and normal or mildly reduced 18F-FDG uptake, indicating viable myocardium. Infected animals with an MPD, in comparison to infected animals without an MPD and control animals, showed a lower left ventricular ejection fraction (P = 0.012), a higher wall motion score index (P = 0.004), and a higher extent of inflammatory infiltration (P = 0.018) but a similar extent of fibrosis (P = 0.15) and similar microvascular diameter and density (P > 0.05). Segments with an MPD (n = 65), as compared with normally perfused regions in the same animal (n = 156), showed a higher wall motion score index (P = 0.005) but a similar extent of inflammatory infiltration, a similar extent of fibrosis, and a similar microvascular diameter and density. Conclusion: Resting MPDs are frequent in experimental CCC and are associated with myocardial inflammation but do not designate scar tissue, corresponding to regions with metabolically viable myocardium.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Nuclear Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectChronic Chagas cardiomyopathypt_BR
dc.subjectMyocardial perfusionpt_BR
dc.subjectMyocardial inflammationpt_BR
dc.subject.otherCardiomiopatia chagásicapt_BR
dc.subject.otherReperfusão miocárdicapt_BR
dc.subject.otherMiocarditept_BR
dc.titleRegional myocardial perfusion disturbance in experimental chronic chagas cardiomyopathypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://jnm.snmjournals.org/content/59/9/1430.longpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3455-2463pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2526-0656pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5026-335Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5035-9172pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6971-1201pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4529-7963pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1673-6456pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1090-8165pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3699-3345pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6553-8387pt_BR
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