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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/47905
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dc.creatorMellanie Karoline do Carmo Félixpt_BR
dc.creatorTúllio Teixeira Deusdarápt_BR
dc.creatorLucas Samuel Soares dos Santospt_BR
dc.creatorRaimundo Wagner de Souza Aguiarpt_BR
dc.creatorRoberto Franco Teixeira Corrêapt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorEliane Macedo Sobrinhopt_BR
dc.creatorBergmann Morais Ribeiropt_BR
dc.creatorLuis André Morais Mariúbapt_BR
dc.creatorPaulo Afonso Nogueirapt_BR
dc.creatorKattyanne Souza Costapt_BR
dc.creatorKelvinson Fernandes Vianapt_BR
dc.creatorAlex Sander Rodrigues Cangussupt_BR
dc.date.accessioned2022-12-13T15:00:51Z-
dc.date.available2022-12-13T15:00:51Z-
dc.date.issued2019-10-01-
dc.citation.volume9pt_BR
dc.citation.spage14082pt_BR
dc.identifier.doi10.1038/s41598-019-50683-2pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/47905-
dc.description.resumoNano-emulsions are promising carriers for antigen delivery. Here, we evaluated the efficacy of a water-oil nano-emulsion containing concentrated, inactivated Clostridium novyi (C. novyi) type B supernatant culture (nano-iCnB) in protecting Swiss mice against a lethal dose of alpha toxin concentrated extract. Proteins were confirmed in the nano-iCnB and their stabilities were determined according physical parameters such as Zeta Potential (ZP). Biochemical, hematological parameters and morphological appearance of liver, spleen and thigh muscle alterations were examined to determine the safety of the compound. Partial protection against lethal doses was achieved in immunized mice despite low IgG titers. These data suggest that our nano-emulsion is a simple and efficient method of promoting antigen delivery for toxin-related diseases.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherAdjuvantes imunológicospt_BR
dc.subject.otherClostridiumpt_BR
dc.subject.otherAntígenospt_BR
dc.titleInactivated alpha toxin from Clostridium novyi type B in nano-emulsion protect partially protects Swiss mice from lethal alpha toxin challengept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773766/pt_BR
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