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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/48335
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dc.creatorRoberta Coutopt_BR
dc.creatorMaria Fernanda Rodriguespt_BR
dc.creatorLeila Ferreirapt_BR
dc.creatorIvana Márcia Alves Dinizpt_BR
dc.creatorFernando Silvapt_BR
dc.creatorTalita Lopezpt_BR
dc.creatorRafael Rodrigues Limapt_BR
dc.creatorMarcia Martins Marquespt_BR
dc.date.accessioned2022-12-22T00:04:47Z-
dc.date.available2022-12-22T00:04:47Z-
dc.date.issued2020-06-28-
dc.citation.volume10pt_BR
dc.citation.issue07pt_BR
dc.citation.spage01pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.3390/biom10070972pt_BR
dc.identifier.issn2218-273Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48335-
dc.description.resumoThe purpose of this study was to analyze in vitro the biological effects on human dental pulp stem cells triggered in response to substances leached or dissolved from two experimental cements for dental pulp capping. The experimental materials, based on extracts from Copaifera reticulata Ducke (COP), were compared to calcium hydroxide [Ca(OH)2] and mineral trioxide aggregate (MTA), materials commonly used for direct dental pulp capping in restorative dentistry. For this, human dental pulp stem cells were exposed to COP associated or not with Ca(OH)2 or MTA. Cell cytocompatibility, migration, and differentiation (mineralized nodule formation (Alizarin red assay) and gene expression (RT-qPCR) of OCN, DSPP, and HSP-27 (genes regulated in biomineralization events)) were evaluated. The results showed that the association of COP reduced the cytotoxicity of Ca(OH)2. Upregulations of the OCN, DSPP, and HSP-27 genes were observed in response to the association of COP to MTA, and the DSPP and HSP-27 genes were upregulated in the Ca(OH)2 + COP group. In up to 24 h, cell migration was significantly enhanced in the MTA + COP and Ca(OH)2 + COP groups. In conclusion, the combination of COP with the currently used materials for dental pulp capping [Ca(OH)2 and MTA] improved the cell activities related to pulp repair (i.e., cytocompatibility, differentiation, mineralization, and migration) including a protective effect against the cytotoxicity of Ca(OH)2pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomoleculespt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherResin cementspt_BR
dc.subject.otherFabaceaept_BR
dc.subject.otherDental pulp cappingpt_BR
dc.subject.otherDental pulppt_BR
dc.subject.otherCalcium hydroxidept_BR
dc.subject.otherBiomineralizationpt_BR
dc.subject.otherGene expressionpt_BR
dc.titleEvaluation of resin-based material containing copaiba oleoresin (copaifera reticulata duck): biological effects on the human dental pulp stem cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2218-273X/10/7/972pt_BR
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