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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/48366
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dc.creatorIsabella Bittencourt do Vallept_BR
dc.creatorRafaela Férrer de Oliveirapt_BR
dc.creatorLarissa Fassarela Marquiorept_BR
dc.creatorSoraia Macaript_BR
dc.creatorFlávio Almeida do Amaralpt_BR
dc.creatorHumberto Jácome-santospt_BR
dc.creatorLucíola Silva Barcelospt_BR
dc.creatorGustavo Batista Menezespt_BR
dc.creatorMárcia Martins Marquept_BR
dc.creatorAlexander Birbrairpt_BR
dc.creatorIvana Márcia Alves Dinizpt_BR
dc.creatorPedro Henrique Dias Moura Prazerespt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorTarcília Aparecida Silvapt_BR
dc.creatorHortência Maciel de Castro Oliveirapt_BR
dc.creatorPollyana Ribeiro Castropt_BR
dc.creatorIuri Dornelas Prates Freitaspt_BR
dc.creatorSicília Rezende Oliveirapt_BR
dc.creatorNatália Aparecida Gomespt_BR
dc.date.accessioned2022-12-22T15:44:10Z-
dc.date.available2022-12-22T15:44:10Z-
dc.date.issued2020-11-06-
dc.citation.volume10pt_BR
dc.citation.issue1pt_BR
dc.citation.spage01pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-020-76243-7pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48366-
dc.description.resumoPhotobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm2, 5 J/cm2, 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent pericyte subpopulation (Type-2 pericytes) in the photoactivated wounds in comparison to the controls. Doppler analysis showed a significant increase in the blood flow in the photoactivated wounds, while marked vascular supply was observed histologically. Histochemical analysis has indicated more advanced stages of tissue repair after photoactivation. These data suggest that photobiomodulation significantly accelerates tissue repair through its vascular effects with direct recruitment of pericytes to the injury site.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - FACULDADE DE ODONTOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherWounds and injuriespt_BR
dc.subject.otherCellspt_BR
dc.subject.otherBloodpt_BR
dc.subject.otherTissuespt_BR
dc.titlePhotobiomodulation drives pericyte mobilization towards skin regenerationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-020-76243-7pt_BR
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