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http://hdl.handle.net/1843/48366| Tipo: | Artigo de Periódico |
| Título: | Photobiomodulation drives pericyte mobilization towards skin regeneration |
| Autor(es): | Isabella Bittencourt do Valle Rafaela Férrer de Oliveira Larissa Fassarela Marquiore Soraia Macari Flávio Almeida do Amaral Humberto Jácome-santos Lucíola Silva Barcelos Gustavo Batista Menezes Márcia Martins Marque Alexander Birbrair Ivana Márcia Alves Diniz Pedro Henrique Dias Moura Prazeres Ricardo Alves Mesquita Tarcília Aparecida Silva Hortência Maciel de Castro Oliveira Pollyana Ribeiro Castro Iuri Dornelas Prates Freitas Sicília Rezende Oliveira Natália Aparecida Gomes |
| Resumo: | Photobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm2, 5 J/cm2, 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent pericyte subpopulation (Type-2 pericytes) in the photoactivated wounds in comparison to the controls. Doppler analysis showed a significant increase in the blood flow in the photoactivated wounds, while marked vascular supply was observed histologically. Histochemical analysis has indicated more advanced stages of tissue repair after photoactivation. These data suggest that photobiomodulation significantly accelerates tissue repair through its vascular effects with direct recruitment of pericytes to the injury site. |
| Assunto: | Wounds and injuries Cells Blood Tissues |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - FACULDADE DE ODONTOLOGIA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1038/s41598-020-76243-7 |
| URI: | http://hdl.handle.net/1843/48366 |
| Data do documento: | 6-Nov-2020 |
| metadata.dc.url.externa: | https://www.nature.com/articles/s41598-020-76243-7 |
| metadata.dc.relation.ispartof: | Scientific Reports |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Photobiomodulation drives pericyte mobilization towards skin regeneration.pdf | 8.25 MB | Adobe PDF | Visualizar/Abrir |
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