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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/48413
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dc.creatorDaniela Augusta Barbato-Ferreirapt_BR
dc.creatorSara Ferreira Dos Santos Costapt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorJuliana Vilela Bastospt_BR
dc.date.accessioned2022-12-23T12:06:29Z-
dc.date.available2022-12-23T12:06:29Z-
dc.date.issued2020-08-07-
dc.citation.volume34pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2020.vol34.0087pt_BR
dc.identifier.issn1807-3107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48413-
dc.description.resumoAbstract: Inflammatory external root resorption (IERR) is a pathological process defined by the progressive loss of dental hard tissue, dentin, and cementum, resulting from the combination of the loss of external root protective apparatus and root canal infection. It has been suggested that healing patterns after tooth replantation may be influenced by the genetic and immunological profiles of the patients. The purpose of the present investigation was to evaluate the DNA methylation patterns of 22 immune response-related genes in extracted human teeth presenting with IERR. Methylation assays were performed on samples of root fragments showing IERR and compared with healthy bone tissue collected during the surgical extraction of impacted teeth. The methylation patterns were quantified using EpiTect Methyl II Signature Human Cytokine Production PCR Array. The results revealed significantly higher hypermethylation of the FOXP3 gene promoter in IERR (65.95%) than in the bone group (23.43%) (p < 0.001). The ELANE gene was also highly methylated in the pooled IERR sample, although the difference was not statistically significant (p= 0.054). Our study suggests that the differential methylation patterns of immune response-related genes, such as FOXP3 and ELANE, may be involved in IERR modulation, and this could be related to the presence of root canal infection. However, further studies are needed to corroborate these findings to determine the functional relevance of these alterations and their role in the pathogenesis of IERR.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEpigenomicspt_BR
dc.subjectMethylationpt_BR
dc.subjectInflammationpt_BR
dc.subjectReplantationpt_BR
dc.subjectRoot resorptionpt_BR
dc.subject.otherEpigenomicspt_BR
dc.subject.otherMethylationpt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherReplantationpt_BR
dc.subject.otherRoot resorptionpt_BR
dc.subject.otherTooth extractionpt_BR
dc.titleDna methylation patterns of immune response-related genes in inflammatory external root resorptionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/34YhKTPhSWG3HVmZPKBMfdv/?lang=enpt_BR
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