1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/49252
Full metadata record
DC FieldValueLanguage
dc.creatorNathálya Gardênia de Holanda Marinho Nogueirapt_BR
dc.creatorMariane Faria Braga Bacelarpt_BR
dc.creatorBárbara de Paula Ferreirapt_BR
dc.creatorJuliana Otoni Parmapt_BR
dc.creatorGuilherme Menezes Lagept_BR
dc.date.accessioned2023-01-31T11:44:33Z-
dc.date.available2023-01-31T11:44:33Z-
dc.date.issued2019-01-
dc.citation.volume144pt_BR
dc.citation.spage223pt_BR
dc.citation.epage232pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2018.11.002pt_BR
dc.identifier.issn1873-2747pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/49252-
dc.description.resumoThe influence of individual differences in cognition and behavior may be partly explained by the different genetic polymorphisms. Among the genetic polymorphisms capable of altering cognitive and behavioral functions, the catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates the availability of dopamine (DA) in the prefrontal cortex and has a trimodal distribution in the population. The Met allele has higher DA availability in the synaptic clefts and can be associated with cognitive stability. Val homozygous individuals exhibit lower DA concentrations in the synaptic clefts, which can be associated with cognitive flexibility. Heterozygotes have intermediate DA concentrations in the synaptic clefts. In the perspective of motor behavior, greater cognitive stability would be advantageous when the practice requires maintenance and refinement of a movement pattern, while a greater cognitive flexibility would be fundamental for practices demanding motor adaptation caused by disturbances. Thus, this integrative review aimed to analyze, in healthy populations, possible associations between the COMT polymorphism and motor behavior, as well as to investigate whether the effects of the COMT genotypes from the perspective of the roles played by tonic and phasic DA are associated with the stability/flexibility required by the nature of the motor task. The search for the articles was carried out in the PubMed, ISI Web of Science and Scopus databases. Six studies that met all the requirements specified in the inclusion criteria were selected. Results suggest an association between COMT polymorphism and motor behavior. Conflicting results regarding the effects of the different COMT polymorphisms on adaptation and sequential motor tasks were found, as well as on the roles played by tonic and phasic DA. Despite the inconsistencies encountered, it was possible to identify that the different COMT genotypes lead to different effects in relation to the nature of the practiced motor task. Due to the reduced number of articles investigating the association between COMT polymorphism and motor behavior, relevant questions about this relation remain under-investigated.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrain Research Bulletinpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMotor learningpt_BR
dc.subjectMotor controlpt_BR
dc.subjectCatechol-O-methyltransferasept_BR
dc.subjectGeneticspt_BR
dc.subjectDopaminept_BR
dc.subjectCognitionpt_BR
dc.subject.otherAprendizagem motorapt_BR
dc.subject.otherCapacidade motorapt_BR
dc.subject.otherMetiltransferasespt_BR
dc.subject.otherGenéticapt_BR
dc.subject.otherDopaminapt_BR
dc.subject.otherCogniçãopt_BR
dc.titleAssociation between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: a study reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0361923018305458?via%3Dihubpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-0286-7559pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1885-6096pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3118-9921pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8296-3676pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.