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http://hdl.handle.net/1843/49387| Type: | Artigo de Periódico |
| Title: | Topological control of supramolecular crystal structures of phenylene bis-monothiooxamate derivatives and in vitro anticancer activity |
| Authors: | Tamyris Teixeira da Cunha Willian Xerxes Coelho Oliveira Ivana Marques Marzano Carlos Basílio Pinheiro Elene Cristina Pereira Maia Cynthia Lopes Martins Pereira |
| Abstract: | This paper describes the synthesis, physical characterization, X-ray crystal structures and antitumoral activity against human carcionogenic cells of three new diethyl ester acid derivatives of phenylene bis-monothiooxamate compounds, namely Et2H2opbta (1), Et2H2mpbta (2) and Et2H2ppbta (3) [opbta = N,N′-1,2-phenylenebis(2-thiooxamate), mbpta = N,N′-1,3-phenylenebis(2-thiooxamate) and ppbta = N,N′-1,4-phenylenebis(2-thiooxamate)]. Compounds 1–3 were obtained under mild conditions by reaction of the corresponding N,N′-phenylenebis(oxamate) analogues and Lawesson's reagent resulting in the formation of C==S bonds at the carbonyl amide functions. Crystal structures of 1–3 consist of 1D supramolecular assemblies of centrosymmetric H2Et2ppbta (3) or noncentrosymmetric chiral H2Et2opbta (1) and H2Et2mpbta (2) molecules with opposite helical chirality (M and P enantiomers) resulting from intermolecular N - H⋯O (1 and 3) or N-H⋯S (2) hydrogen bonds between the amide hydrogen atoms and the carbonyl ester oxygen or thionyl amide sulfur atoms from the thiooxamate moieties respectively, together with weak S⋯S bonds between the thionyl amide sulfur atoms (1). The cytotoxicity of H2Et2xpbta [x = o (1), m (2) and p (3)] against chronic myelogenous leukemia cells was evaluated and the bioactivity follows the order 1 >> 2 > 3, compound 1 being six and ten times more active than 2 and 3, respectively. |
| Subject: | Química supramolecular Cristalografia Cristalografia de raio X Estrutura molecular Síntese orgânica Compostos organossulfurados Testes químicos e reagentes Agentes antineoplasicos Leucemia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.molstruc.2017.08.051 |
| URI: | http://hdl.handle.net/1843/49387 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0022286017311183 |
| metadata.dc.relation.ispartof: | Journal of Molecular Structure |
| Appears in Collections: | Artigo de Periódico |
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