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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/49430
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dc.creatorSamuel Monzempt_BR
dc.creatorDábila Araújo Sônegopt_BR
dc.creatorAndresa de Cássia Martinipt_BR
dc.creatorAna Paula Bispo Dantas Mourapt_BR
dc.creatorFelipe Gomes da Silvapt_BR
dc.creatorJorge Luiz Brito de Fariapt_BR
dc.creatorRoberto Lopes de Souzapt_BR
dc.date.accessioned2023-02-02T12:58:32Z-
dc.date.available2023-02-02T12:58:32Z-
dc.date.issued2018-09-
dc.citation.volume98pt_BR
dc.citation.spage88pt_BR
dc.citation.epage91pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.vibspec.2018.07.013pt_BR
dc.identifier.issn1873-3697pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/49430-
dc.description.resumoIn this work, we correlate Raman spectroscopy in vivo which is performed in healthy bone tibia, 3-month-old mice with osteoporotic bone, within two groups: OVX (ovariectomized) and sham (lumbar access, no ovariectomy group control). Laser beam was applied directly in a punch of skin in the distal medial part of tibia. To access bone quality, we calculate mineral/matrix ratio, relative lipid and proteoglycan content as well as the crystallinity using normalized spectrum within the integrated area method. The variables obtained for bone quality were statistically verify by ANOVA and tested for normality, where differences were considered to be significant for P < 0.05. In osteoporotic bone (OVX) we found a decreasing ratio between mineral to matrix and relative proteoglycan content, followed by a relative increasing lipid content when comparing with healthy bone (Sham) with statistical significance. The crystallinity showed higher value for OVX group but without statistical significance. Our Confocal Raman Spectroscopy provides a well-controlled environment to differentiate osteoporotic bone from healthy bone by decreasing calcium and glycosaminoglycans and increasing the amount of lipids in the cortical tibia of the mouse in vivo.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVibrational Spectroscopypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherRaman, Espectroscopia dept_BR
dc.subject.otherHidroxiapatitapt_BR
dc.subject.otherOsteoporosept_BR
dc.subject.otherTíbiapt_BR
dc.titleRaman spectroscopic of osteoporosis model in mouse tibia in vivopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S092420311830122Xpt_BR
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