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http://hdl.handle.net/1843/50037| Type: | Artigo de Periódico |
| Title: | Copper complexes and carbon nanotube–copper ferrite-catalyzed benzenoid A-ring selenation of quinones: an efficient method for the synthesis of trypanocidal agents |
| Authors: | Guilherme Augusto de Melo Jardim Icaro Antônio Oliveira Bozzi Willian Xerxes Coelho Oliveira Camila Mesquita Rodrigues Rubem Figueiredo Sadok Menna Barreto Ramar Arun Kumar Edmond Gravel Eric Doris Antonio Luiz Braga Eufrânio Nunes da Silva Júnior |
| Abstract: | We report a new method for A-ring selenation of naphthoquinones and anthraquinones and discuss the relevant trypanocidal activity of the synthesized compounds. We have demonstrated three efficient strategies for the preparation of the target selenium derivatives, i.e. (a) copper(I) thiophene-2-carboxylate and in situ generated Santi's reagent were used to prepare selenium-substituted benzenoid quinones, (b) copper complexes and (c) carbon nanotube-supported copper ferrite as catalysts in the presence of AgSeR-salts were also used for the synthesis of selenium-containing quinoidal derivatives. These new methods provide efficient and practical strategies for the preparation of selenium-based quinones. In addition, we have discovered nine compounds with potent trypanocidal activity. The derivatives 2a–2e showed potent trypanocidal activity with IC50 values in the range of 13.3 to 37.0 μM. |
| Subject: | Síntese orgânica Compostos orgânicos Selênio Antraquinonas Cristalografia de raio X Nanotubos de carbono Agentes antineoplasicos Complexos metálicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1039/C9NJ02026H |
| URI: | http://hdl.handle.net/1843/50037 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj02026h |
| Appears in Collections: | Artigo de Periódico |
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