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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50561
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dc.creatorVinicius Dias Wilsonpt_BR
dc.creatorClaire Thomaspt_BR
dc.creatorEmilie Passerieuxpt_BR
dc.creatorGérald Hugonpt_BR
dc.creatorFabien Pillardpt_BR
dc.creatorAndré Gustavo Pereira de Andradept_BR
dc.creatorSébastien Bommartpt_BR
dc.creatorMarie-Christine Picotpt_BR
dc.creatorJoël Pincemailpt_BR
dc.creatorJacques Mercierpt_BR
dc.creatorSandrine Arbogastpt_BR
dc.creatorDalila Laoudj-Chenivessept_BR
dc.date.accessioned2023-03-01T14:18:51Z-
dc.date.available2023-03-01T14:18:51Z-
dc.date.issued2018-01-
dc.citation.volume1pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1002/j.2617-1619.2018.tb00002.xpt_BR
dc.identifier.issn2617-1619pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50561-
dc.description.resumoAims: Facioscapulohumeral muscular dystrophy (FSHD) causes progressive muscle weakness and loss. This study aims to compare changes in quadriceps oxygenation and hemodynamics during maximal voluntary quadriceps isometric contraction (MVCQ) and to determine the relationships between these parameters and systemic oxidative stress markers and muscle structural parameters and muscle volume in patients with FSHD and healthy controls. Methods and results: 17 patients with FSHD and 14 sedentary healthy controls were matched for age and physical activity level. Blood antioxidant status and stress markers were evaluated. The quadriceps tissue oxygenation index was evaluated by near infrared spectroscopy during MVCQ. Quadriceps volume was determined by magnetic resonance imaging. Quadriceps muscle samples were obtained to evaluate muscle fiber typology and mitochondria morphology by transmission electron microcopy (TEM). Groups were compared by the unpaired Student t-test or by the non-parametric Kruskal - Wallis test in case of skewed distributions with p<0.05. Associations were assessed by Spearman correlations. Compared to controls, patients with FSHD displayed a significantly lower local O2 consumption per second that was correlated with significantly lower MVCQ and systemic oxidative stress marker levels. Although no difference in muscle typology was observed between groups, TEM showed abnormal aggregation of mitochondria near blood capillaries in FSHD muscles. Conclusions: These results suggest that patients with FSHD have a lower O2 demand during MVCQ and that TOI measured by NIRS during MVC could be useful to determine the muscle oxidative capacity. Furthermore, these adaptations are related to the muscle structure reorganization linked to the occurrence of oxidative stress.pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Musclept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFacioscapulohumeral muscular dystrophypt_BR
dc.subjectNear infrared spectroscopypt_BR
dc.subjectMagnetic resonance imagingpt_BR
dc.subjectMaximal voluntary contractionpt_BR
dc.subjectOxidative stresspt_BR
dc.subject.otherDistrofia muscularpt_BR
dc.subject.otherEspectroscopia de infravermelhopt_BR
dc.subject.otherImagem de ressonancia magneticapt_BR
dc.subject.otherContração muscularpt_BR
dc.subject.otherEstresse oxidativopt_BR
dc.titleImpaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/j.2617-1619.2018.tb00002.xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0184-5438pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3381-9744pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-3406-4558pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4204-7299pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5228-2255pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4356-9187pt_BR
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