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http://hdl.handle.net/1843/50603| Type: | Artigo de Periódico |
| Title: | Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process |
| Authors: | Carolina Rossi Gouvêa Silva Sílvia Ligório Fialho Jamile Barbosa Bárbara Caroline Rodrigues de Araújo Guilherme Carneiro Rita de Cássia de Oliveira Sebastião Wagner da Nova Mussel Maria Irene Yoshida Maria Betânia de Freitas Marques |
| Abstract: | Azathioprine is an immunosuppressive drug for several inflammatory disorders. Due to its clinical relevance, to explore the solid-state properties for excipient compatibility in the product quality review process is essential. Fourier transform infrared spectroscopy, powder X-ray diffraction and thermal analysis (thermogravimetry/derivative thermogravimetry (TG/DTG), differential thermal analysis (DTA), and differential scanning calorimetry (DSC)) were applied. The compatibility studies evidenced that starch pregelatinized, colloidal silicon dioxide, and talc are fully compatible with azathioprine. However, stearic acid, magnesium stearate, and mannitol are incompatible after heat supply at temperatures easily reached by industrial processing. The nonlinear Vyazovkin isoconversional treatment performed the kinetic study of the thermal degradation. The activation energies were determined to clarify the influence of each excipient on the thermal drug stability, an essential procedure in the pharmaceutical development, and all over the commercial live span, in Good Manufacturing Practices. |
| Subject: | Química farmacêutica Cinética química Fourier, Espectroscopia de infravermelho por transformada de Raios X - Difração Análise térmica Termogravimetria Calorimetria Tecnologia farmacêutica - Controle de qualidade Medicamentos - Análise Excipientes |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://dx.doi.org/10.21577/0103-5053.20200218 |
| URI: | http://hdl.handle.net/1843/50603 |
| Issue Date: | Mar-2021 |
| metadata.dc.url.externa: | https://jbcs.sbq.org.br/default.asp?ed=309 |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process.pdf | 7.04 MB | Adobe PDF | View/Open |
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