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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50620
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dc.creatorOtávio Cardoso Filhopt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorMatheus Ferreira Ináciopt_BR
dc.creatorLudmilla Regina Souzapt_BR
dc.creatorRenata Danielle Ribeiropt_BR
dc.creatorRaynald Lício Ferreira Brandão Silvapt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorRenê Ferreira Costapt_BR
dc.creatorEduardo Robson Duartept_BR
dc.creatorFranciellen Morais Costapt_BR
dc.date.accessioned2023-03-03T11:25:48Z-
dc.date.available2023-03-03T11:25:48Z-
dc.date.issued2018-09-29-
dc.citation.volume8pt_BR
dc.citation.issue9pt_BR
dc.citation.spage22826pt_BR
dc.citation.epage22831pt_BR
dc.identifier.issn2230-9926pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50620-
dc.description.resumoAnnona crassiflora Mart. is a species of the cerrado biome in the family Annonaceae. It is a vegetable with therapeutic potential. However, it should be emphasized that its toxicity when consumed in large doses remains unknown, and clinical studies are strongly suggested for this purpose. The objective of this study was to verify the toxicological effect of leaf and seed extracts of Annona crassiflora Mart. (Annonaceae) in mice. The plant was collected in were collected in cerrado areas in Montes Claros, Minas Gerais, Brazil. Healthy leaves and seeds were selected and dried in a forced air circulating dryer at 40ºC for 72 h. Ethanolic extract (EE) was obtained by maceration of the dried leaves in absolute ethanol. The extracts were filtered and subsequently dehydrated at 40ºC for 48 h. The chromatographic profile was performed using an HPLC system. To evaluate the toxicological effects, 18 Swiss mice, were divided into three groups, composed of three males and three females each as follows: 22 μL PBS (C), 22 μL leaf extract (LE), 22 μL seed extract (SE) that were administered by means of gavage at cumulative doses for four days at the following concentrations: day one, 12.5mg/kg; day two, 25.0mg/kg; day three 50mg/kg and the fourth day, 100mg/kg. To assess the toxicological effects, physical aspects, behavior, and body weight of animals were monitored daily. On the fifth day the mice were euthanized and peripheral blood and target tissues were collected. ALT plasma level was measured. Liver, spleen, heart, and kidney samples were collected, formalin-fisxed, paraffin-embedded, and submited to histopathological analysis. Statistical analysis was performed using Student t tests and ANOVA. The Bonferroni test was applied as post hoc. Valeus of p < 0.05 were considered as statistically significant. Our findings showed that A. crassiflora Mart. extract is rich in flavonoids and flavones. No clinical signs or symptoms that had suggested toxicity were observed in all animals. However LE and SE animals showed decreased body weight, increased size and wight for liver and spleen organs. Moreover, ALT levels were increased in experimental animals. Histological analysis showed morphological findings of discrete hyperemia in liver and spleen tissues of animals treated with SE. In conclusion, the present study evidenced potential toxic effects of A.crassiflora Mart. leaf and seed extract notably in liver and spleen organs. More prospective studies are needed to better understand the cytotoxic effects of A. crassiflora.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherAnonaceapt_BR
dc.subject.otherToxicidade - Testespt_BR
dc.subject.otherCamundongospt_BR
dc.titleEffects of leaf and seed alcoholic extracts from of Annona crassiflora Mart. (Annonaceae) in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.journalijdr.com/effects-leaf-and-seed-alcoholic-extracts-annona-crassiflora-mart-annonaceae-micept_BR
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