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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50648
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dc.creatorSumaia Araújo Pirespt_BR
dc.creatorWagner da Nova Musselpt_BR
dc.creatorMaria Irene Yoshidapt_BR
dc.date.accessioned2023-03-03T18:18:32Z-
dc.date.available2023-03-03T18:18:32Z-
dc.date.issued2017-
dc.citation.volume127pt_BR
dc.citation.issue1pt_BR
dc.citation.spage535pt_BR
dc.citation.epage542pt_BR
dc.identifier.doihttps://doi.org/10.1007/s10973-016-5769-zpt_BR
dc.identifier.issn1588-2926pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50648-
dc.description.resumoDifferential scanning calorimetry (DSC) has been used in combination with powder X-ray diffraction (PXRD) and solid-state nuclear magnetic resonance (SSNMR) for evaluation of drug–excipient interaction. This study aimed to evaluate the antidepressive citalopram hydrobromide and the most usual excipient commonly used for the evaluation of their compatibility in binary mixtures. The TG/DTG curves reveal that citalopram is thermally stable up to 230 °C, presenting a sharp endothermic peak at 183 °C (T onset = 185 °C) that corresponds to its melting point. Only for citalopram–lactose binary mixture was observed dislocation of the melting event in the DSC curves; however, this change has not indicated to be an interaction between the components in this case, but an overlap of events of lactose and citalopram. PXRD pattern suggests that no interaction is present between individual components that still showing the same crystalline structure for citalopram. The SSNMR spectrum assignment was done based on computational prediction of chemical shifts comparing it with its original spectrum. The chemical shifts confirmed the expected structure. Therefore, since changes in chemical shift are smaller than 1 ppm, no evidence of chemical interaction between the components of each binary mixture was confirmed.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCitaloprampt_BR
dc.subjectCompatibility studiespt_BR
dc.subjectThermal analysispt_BR
dc.subjectPXRDpt_BR
dc.subjectSSNMRpt_BR
dc.subject.otherAnálise térmicapt_BR
dc.subject.otherCalorimetriapt_BR
dc.subject.otherRaios X - Difraçãopt_BR
dc.subject.otherRessonância magnética nuclearpt_BR
dc.subject.otherMedicamentos - Estabilidadept_BR
dc.subject.otherPolimorfismo (Cristalografia)pt_BR
dc.subject.otherQuímica do estado sólidopt_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.subject.otherExcipientespt_BR
dc.subject.otherFármacospt_BR
dc.subject.otherAntidepressivospt_BR
dc.titleSolid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniquespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s10973-016-5769-zpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7611-7545pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9768-9830pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6795-9457pt_BR
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