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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50729
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dc.creatorCamila Santos Pereirapt_BR
dc.creatorMarcos Vinícius Macedo de Oliveirapt_BR
dc.creatorLudmilla Regina de Souzapt_BR
dc.creatorOtávio Cardoso Filhopt_BR
dc.creatorValéria Couto Quintãopt_BR
dc.creatorAndréia Brito de Souzapt_BR
dc.creatorMarcos Vinícius Mendes Barrosopt_BR
dc.creatorLuiz Henrique da Silveirapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2023-03-08T11:59:49Z-
dc.date.available2023-03-08T11:59:49Z-
dc.date.issued2019-07-
dc.citation.volume6pt_BR
dc.citation.issue7pt_BR
dc.citation.spage90pt_BR
dc.citation.epage98pt_BR
dc.identifier.doi10.22161/ijaers.6712pt_BR
dc.identifier.issn2456-1908pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50729-
dc.description.resumoThe current study evaluated the proliferation index and immunohistochemical expression of SIRT1 on normal skin and cutaneous melanocytic nevi (CMN) and cutaneous malignant melanoma (CMM). Formalin-fixed paraffin-embedded tissue samples from 43 CMN, 22 CMM and 10 normal skin were obtained and clinical data were abstracted from the electronic medicalrecord.SIRT1 and Ki67 proteins expressions were evaluated regarding to clinic pathological behavior in CMM. The level of significance was set at α = 5% (p < 0.05).Our findings showed that SIRT1 positivity was significantly higher in benign melanocytic nevi than that in cutaneous malignant melanoma (p=0.002). As expected, the proliferation index was significantly higher in samples of cutaneous malignant melanoma as compared to the normal skin and melanocytic nevi (p=0.001). However, the expression of Ki67 protein was not also significantly related to the expression of SIRT1 (p > 0.05). In conclusion, low expression of SIRT1 and high proliferation index may play an important role in progression of cutaneous melanoma.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Advanced Engineering Research and Science (IJAERS)-
dc.rightsAcesso Abertopt_BR
dc.subject.otherPele - Câncerpt_BR
dc.subject.otherMelanomapt_BR
dc.subject.otherNevopt_BR
dc.titleSIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://ijaers.com/detail/sirt1-and-ki67-immunohistochemical-expression-in-progression-of-cutaneous-malignant-melanoma/pt_BR
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