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http://hdl.handle.net/1843/50855| Type: | Artigo de Periódico |
| Title: | Evaluation of antitumor activity of long-circulating and ph-sensitive liposomes containing ursolic acid in animal models of breast tumor and gliosarcoma. |
| Authors: | Talita Guieiro Ribeiro Rocha Sávia Caldeira de Araújo Lopes Geovani Dantas Cassali Ênio Ferreira Emerson Soares Veloso Geovanni Dantas Cassali Enio Ferreira Emerson Soares Veloso Elaine Amaral Leite Fernão Castro Braga Lucas Antônio Miranda Ferreira Daniel Balvay Anikitos Garofalakis Mônica Cristina Oliveira Bertrand Tavitian |
| Abstract: | Ursolic acid (UA) is a triterpene found in different plant species, possessing antitumor activity, which may be a result of its antiangiogenic effect. However, UA has low water solubility, which limits its use because the bioavailability is impaired. To overcome this inconvenience, we developed long-circulating and pH-sensitive liposomes containing ursolic acid (SpHL-UA). We investigated the antiangiogenic effect of free UA and SpHL-UA in murine brain cancer and human breast tumor models by means of determination of the relative tumor volume, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and histopathological analysis. Methods. The animals were treated with dimethyl sulfoxide in 0.9% (w/v) NaCl, free UA, long-circulating and pH-sensitive liposomes without drug (SpHL), or SpHL-UA. The animals were submitted to each treatment by intraperitoneal injection for 5 days. The dose of free UA or SpHL-UA was equal to 23 mg/kg. Results. Tumor growth inhibition was not observed in human breast tumor–bearing animals. For murine gliosarcoma-bearing animals, a slight tumor growth inhibition was observed in the groups treated with free UA or SpHL-UA (9% and 15%, respectively). No significant change in any of the parameters evaluated by DCE-MRI for both experimental models could be observed. Nevertheless, the evaluation of the mean values of magnetic resonance parameters of human breast tumor–bearing animals showed evidence of a possible antiangiogenic effect induced by SpHL-UA. Histopathological analysis did not present significant change for any treatment. Conclusion. SpHL-UA did not show antiangiogenic activity in a gliosarcoma model and seemed to induce an antiangiogenic effect in the human breast tumor model. |
| Subject: | Ácido ursólico Ressonância magnética Câncer de mama Câncer - Cérebro |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | DOI: 10.1177/1534735416628273 |
| URI: | http://hdl.handle.net/1843/50855 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://journals.sagepub.com/doi/epub/10.1177/1534735416628273 |
| metadata.dc.relation.ispartof: | Integrative Cancer Therapies |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Integrative Cancer Therapies_Evaluation of Antitumor Activityof Long-Circulating and pH-Sensitive.pdf | 538.9 kB | Adobe PDF | View/Open |
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