1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50960
Full metadata record
DC FieldValueLanguage
dc.creatorFernanda Alves Borattopt_BR
dc.creatorMarina Santiago Francopt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorGeovanni Dantas Cassalipt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorLucas Antônio Miranda Ferreirapt_BR
dc.creatorElaine Amaral Leitept_BR
dc.date.accessioned2023-03-16T17:53:37Z-
dc.date.available2023-03-16T17:53:37Z-
dc.date.issued2020-
dc.citation.volume144pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejps.2019.105205pt_BR
dc.identifier.issn0928-0987pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50960-
dc.description.resumoDoxorubicin (DOX) plays an important role in cancer treatment; however, high cardiotoxicity and low penetration in solid tumors are the main limitations of its use. Liposomal formulations have been developed to attenuate the DOX toxicity, but the technological enhancement of the liposomal formulation as well as the addition of another agent with antitumor properties, like alpha-tocopheryl succinate (TS), a semi-synthetic analog of vitamin E, could certainly bring benefits. Thus, in this study, it was proposed the development of liposomes composed of DOX and TS (pHSL-TS-DOX). A new DOX encapsulation method, without using the classic ammonium sulfate gradient with high encapsulation percentage was developed. Analysis of Small Angle X-ray Scattering (SAXS) and release study proved the pH-sensitivity of the developed formulation. It was observed stabilization of tumor growth using pHSL-TS-DOX when compared to free DOX. The toxicity tests showed the safety of this formulation since it allowed body weight initial recovery after the treatment and harmless to heart and liver, main target organs of DOX toxicity. The developed formulation also avoided the occurrence of myelosuppression, a typical adverse effect of DOX. Therefore, pHSL-TS-DOX is a promising alternative for the treatment of breast cancer since it has adequate antitumor activity and a safe toxicity profile.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences-
dc.rightsAcesso Restritopt_BR
dc.subjectBreast cancerpt_BR
dc.subjectDoxorubicinpt_BR
dc.subjectAlpha-tocopheryl succinatept_BR
dc.subjectAntitumor activitypt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectPH-sensitivitypt_BR
dc.subject.otherCâncer de mamapt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.titleAlpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0928098719304786pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4610-1328pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5650-6743pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2474-5536pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8812-3811pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.